Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 213285..213880 Replicon chromosome
Accession NZ_CP034449
Organism Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EJ072_RS01250 Protein ID WP_126078229.1
Coordinates 213593..213880 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3S9DEM1
Locus tag EJ072_RS01245 Protein ID WP_042637981.1
Coordinates 213285..213590 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ072_RS01230 210491..211402 + 912 WP_126078226.1 glycoside hydrolase family 26 protein -
EJ072_RS01235 211531..212031 + 501 WP_126078227.1 DUF995 domain-containing protein -
EJ072_RS01240 212122..213279 + 1158 WP_126078228.1 hypothetical protein -
EJ072_RS01245 213285..213590 - 306 WP_042637981.1 putative addiction module antidote protein Antitoxin
EJ072_RS01250 213593..213880 - 288 WP_126078229.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJ072_RS01255 213933..214928 - 996 WP_126078230.1 Rieske 2Fe-2S domain-containing protein -
EJ072_RS01260 214925..216091 - 1167 WP_126078231.1 GNAT family N-acetyltransferase -
EJ072_RS01265 216067..217323 - 1257 WP_126078232.1 CoF synthetase -
EJ072_RS01270 217320..218144 - 825 WP_126078233.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10689.41 Da        Isoelectric Point: 10.2219

>T116081 WP_126078229.1 NZ_CP034449:c213880-213593 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
MIEVRQTADFTNWLDGLRDAAARLRIAARIRRVEIGNIGDVKYFDGIGELRIDHGPGYRLYFVKIGNAVIILLCGGDKSS
QRRDIAKAKQMAKEI

Download         Length: 288 bp

>T116081 NZ_CP034449:c213880-213593 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
ATGATCGAGGTCCGGCAGACGGCCGATTTCACCAACTGGCTGGACGGACTTCGCGACGCTGCGGCTCGCCTGCGCATCGC
TGCCCGCATTCGTCGGGTCGAAATCGGCAACATCGGTGATGTCAAATATTTCGATGGCATCGGCGAACTTCGGATCGACC
ATGGCCCAGGTTACCGGCTCTACTTTGTGAAGATCGGAAACGCCGTGATCATCCTGCTCTGTGGCGGCGACAAGTCCAGC
CAAAGGCGCGACATCGCCAAGGCGAAACAAATGGCAAAGGAGATATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10697.30 Da        Isoelectric Point: 4.6158

>AT116081 WP_042637981.1 NZ_CP034449:c213590-213285 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
MPLETTRFDILDYLKTPEDRLAYIEAAFEDGDPALITHALGDVARSIGMTAVAKEAGVTREALYKALSEKGDPRLSTLLG
VTKALGLQLDVKPIGPGSLGA

Download         Length: 306 bp

>AT116081 NZ_CP034449:c213590-213285 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
ATGCCTCTCGAAACCACTCGCTTCGACATCCTCGATTACCTGAAAACCCCGGAGGATCGCTTGGCCTACATCGAGGCTGC
CTTCGAGGATGGTGATCCTGCGCTCATCACGCATGCGTTGGGCGATGTAGCGCGCTCCATAGGCATGACGGCTGTGGCGA
AAGAAGCTGGCGTCACGCGTGAGGCGCTCTACAAGGCATTGAGCGAAAAGGGCGACCCTCGCCTCAGCACACTGCTGGGT
GTCACCAAGGCGCTTGGTCTGCAACTTGACGTGAAACCTATCGGCCCTGGCTCGCTCGGGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S9DEM1

References