Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2708397..2709025 Replicon chromosome
Accession NZ_CP034448
Organism Mesorhizobium sp. M1B.F.Ca.ET.045.04.1.1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EJ071_RS13265 Protein ID WP_126098271.1
Coordinates 2708639..2709025 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJ071_RS13260 Protein ID WP_126098270.1
Coordinates 2708397..2708642 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ071_RS13230 2703480..2704232 - 753 WP_126102564.1 SDR family oxidoreductase -
EJ071_RS13235 2704286..2705389 - 1104 WP_126098265.1 AbrB family transcriptional regulator -
EJ071_RS13240 2705467..2705778 - 312 WP_126098266.1 antibiotic biosynthesis monooxygenase -
EJ071_RS13245 2705830..2706612 - 783 WP_189521540.1 SDR family oxidoreductase -
EJ071_RS13250 2706693..2707127 - 435 WP_126098268.1 DsrE family protein -
EJ071_RS13255 2707235..2708317 + 1083 WP_126098269.1 hypothetical protein -
EJ071_RS13260 2708397..2708642 + 246 WP_126098270.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EJ071_RS13265 2708639..2709025 + 387 WP_126098271.1 type II toxin-antitoxin system VapC family toxin Toxin
EJ071_RS13270 2709028..2709975 - 948 WP_126098272.1 cation diffusion facilitator family transporter -
EJ071_RS13275 2709981..2712170 - 2190 WP_126098273.1 anthranilate synthase -
EJ071_RS13280 2712460..2713515 - 1056 WP_126098274.1 succinylglutamate desuccinylase/aspartoacylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14382.64 Da        Isoelectric Point: 6.4718

>T116076 WP_126098271.1 NZ_CP034448:2708639-2709025 [Mesorhizobium sp. M1B.F.Ca.ET.045.04.1.1]
VIYLLDTNAVIAIMKGDDDLLKVLKRNKPQDFALSAIVAHELYYGACRGQRTEENLARLDALLFPVLEFDREDARHAGEI
RAMLAVSGTPIGPFDVLIGGQARARSLTLMTRNVREFERIKNLAIETW

Download         Length: 387 bp

>T116076 NZ_CP034448:2708639-2709025 [Mesorhizobium sp. M1B.F.Ca.ET.045.04.1.1]
GTGATCTATCTGCTCGATACCAATGCTGTCATCGCCATCATGAAGGGCGATGATGATTTGCTGAAAGTGCTCAAGCGAAA
CAAGCCGCAAGATTTTGCGCTTTCGGCCATCGTTGCGCACGAGCTCTATTATGGGGCCTGCAGAGGCCAGCGAACGGAAG
AGAATCTCGCACGACTGGACGCCCTTCTGTTCCCGGTACTCGAATTCGATCGGGAAGACGCGCGGCACGCCGGCGAGATT
CGGGCGATGCTGGCGGTATCGGGAACTCCAATTGGTCCCTTTGATGTGCTTATTGGAGGCCAAGCACGTGCCCGCAGCCT
GACGTTGATGACACGAAATGTTCGCGAGTTCGAGCGGATTAAGAATCTGGCTATCGAGACCTGGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9442.64 Da        Isoelectric Point: 4.6558

>AT116076 WP_126098270.1 NZ_CP034448:2708397-2708642 [Mesorhizobium sp. M1B.F.Ca.ET.045.04.1.1]
MNKAKIFWSGRSQAVRLPKEFRFETDEVSIRRHGQTVVLEPLPQDWAWLDQVIGTLDDDFVDAAEERVEEQKRPALGDVF
K

Download         Length: 246 bp

>AT116076 NZ_CP034448:2708397-2708642 [Mesorhizobium sp. M1B.F.Ca.ET.045.04.1.1]
ATGAACAAAGCAAAAATATTCTGGTCAGGCCGCTCGCAGGCCGTCCGCCTGCCGAAGGAGTTTCGCTTTGAAACTGACGA
GGTTTCGATCCGCCGTCATGGGCAGACTGTCGTTCTTGAACCTCTTCCGCAAGATTGGGCATGGCTCGATCAAGTGATCG
GGACACTTGACGACGATTTTGTCGATGCGGCGGAGGAAAGGGTAGAGGAGCAGAAACGGCCCGCTCTCGGCGACGTCTTC
AAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References