Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/DUF1778(antitoxin)
Location 2994352..2994971 Replicon chromosome
Accession NZ_CP034446
Organism Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EJ069_RS14955 Protein ID WP_126061940.1
Coordinates 2994717..2994971 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EJ069_RS14950 Protein ID WP_126061939.1
Coordinates 2994352..2994720 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ069_RS14920 2989883..2990116 + 234 Protein_2939 hypothetical protein -
EJ069_RS14925 2990208..2991320 + 1113 WP_126061935.1 pyridoxal phosphate-dependent aminotransferase -
EJ069_RS14930 2991366..2991850 - 485 Protein_2941 winged helix-turn-helix transcriptional regulator -
EJ069_RS14935 2991999..2992280 + 282 WP_126061936.1 acylphosphatase -
EJ069_RS14940 2992495..2993142 + 648 WP_126061937.1 TetR/AcrR family transcriptional regulator -
EJ069_RS14945 2993192..2994355 + 1164 WP_126061938.1 isovaleryl-CoA dehydrogenase -
EJ069_RS14950 2994352..2994720 - 369 WP_126061939.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EJ069_RS14955 2994717..2994971 - 255 WP_126061940.1 type II toxin-antitoxin system HicA family toxin Toxin
EJ069_RS14960 2995075..2996682 + 1608 WP_126061941.1 methylcrotonoyl-CoA carboxylase -
EJ069_RS14965 2996685..2997221 + 537 WP_126061942.1 O-acetyl-ADP-ribose deacetylase -
EJ069_RS14975 2997532..2999493 + 1962 WP_126061943.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-77)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9422.92 Da        Isoelectric Point: 11.4362

>T116069 WP_126061940.1 NZ_CP034446:c2994971-2994717 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
MKAAHRQTLDKIFANPVSASIKWRDVETLLVALGARVSEGRGSRVRFTLNGITLRVHRPHPSPDTKAYVVREIRTFLIDS
GVEL

Download         Length: 255 bp

>T116069 NZ_CP034446:c2994971-2994717 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
ATGAAAGCGGCGCACCGGCAGACACTGGACAAGATATTTGCGAACCCGGTCAGCGCCTCGATCAAATGGCGCGATGTCGA
GACGTTGTTGGTGGCGCTCGGAGCGCGAGTGTCGGAAGGGCGTGGATCGCGGGTGCGCTTCACGTTGAACGGGATAACGC
TTCGAGTGCATCGACCGCATCCATCGCCAGACACGAAAGCATACGTGGTCCGCGAGATCAGGACTTTCCTAATAGATTCG
GGTGTTGAGCTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13806.48 Da        Isoelectric Point: 5.2842

>AT116069 WP_126061939.1 NZ_CP034446:c2994720-2994352 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
MKPYKGYLGTIEFDENDVVFHGRIIGIRDIFTYEADSAEELLKAFHECVDDYLEFCAEENKEPEKPFSGKLALRTTPEVH
RLVSRAAASDGKSINQWVSDALAEAARKRVDEGSTKVKTRTH

Download         Length: 369 bp

>AT116069 NZ_CP034446:c2994720-2994352 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
ATGAAGCCCTACAAGGGATATCTGGGAACGATCGAGTTCGATGAAAACGACGTTGTATTTCACGGTCGTATCATAGGTAT
TCGCGACATCTTCACATACGAAGCCGATTCGGCGGAAGAGTTGCTGAAGGCCTTTCATGAATGCGTTGACGACTATCTGG
AATTTTGCGCTGAAGAGAACAAGGAACCGGAAAAGCCTTTTTCGGGCAAACTCGCTCTGCGCACCACGCCCGAGGTTCAT
CGTCTTGTCAGCCGGGCCGCTGCCAGTGACGGAAAATCGATAAATCAATGGGTGTCGGACGCTCTCGCAGAAGCGGCGCG
CAAGCGCGTCGACGAAGGGTCGACCAAGGTCAAAACCCGCACTCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References