Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 623725..624392 Replicon chromosome
Accession NZ_CP034446
Organism Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EJ069_RS02990 Protein ID WP_126060011.1
Coordinates 623994..624392 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJ069_RS02985 Protein ID WP_126060010.1
Coordinates 623725..623994 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ069_RS02960 618958..619944 + 987 WP_126060007.1 ABC transporter permease -
EJ069_RS02965 620016..620483 + 468 WP_126064613.1 gluconokinase -
EJ069_RS02970 620499..621644 - 1146 WP_126060008.1 hypothetical protein -
EJ069_RS02975 621808..622257 - 450 WP_040970141.1 Rrf2 family transcriptional regulator -
EJ069_RS02980 622508..623494 - 987 WP_126060009.1 sulfate ABC transporter substrate-binding protein -
EJ069_RS02985 623725..623994 + 270 WP_126060010.1 antitoxin Antitoxin
EJ069_RS02990 623994..624392 + 399 WP_126060011.1 type II toxin-antitoxin system VapC family toxin Toxin
EJ069_RS02995 624408..625448 - 1041 WP_126060012.1 sulfate/molybdate ABC transporter ATP-binding protein -
EJ069_RS03000 625518..626402 - 885 WP_126060013.1 sulfate ABC transporter permease subunit CysW -
EJ069_RS03005 626395..627246 - 852 WP_126060014.1 sulfate ABC transporter permease subunit CysT -
EJ069_RS03010 627310..628338 - 1029 WP_126060015.1 sulfate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14053.28 Da        Isoelectric Point: 5.2069

>T116065 WP_126060011.1 NZ_CP034446:623994-624392 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
MRFMLDTNIISDMIRNPAGKAAGAMARAGDAAVCTSIVVASELRYGCARKGSANLLKKVEELLAELPVLPLDVPVDAEYG
VLRAELEGRGETIGHNDLFIAAHACALGTTLVTANTAEFARIGKLKVENWLE

Download         Length: 399 bp

>T116065 NZ_CP034446:623994-624392 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
ATGCGGTTCATGCTCGACACGAACATCATAAGCGACATGATCCGAAACCCGGCCGGCAAGGCTGCTGGCGCTATGGCGCG
CGCGGGCGACGCCGCCGTCTGCACCAGCATCGTGGTTGCTTCCGAATTGCGTTATGGCTGCGCCAGGAAGGGATCGGCCA
ACCTGCTCAAGAAGGTCGAGGAATTGCTGGCCGAGCTTCCCGTCCTGCCGCTCGATGTGCCGGTTGATGCCGAGTACGGC
GTGCTCCGTGCCGAGCTGGAAGGCAGAGGCGAGACCATCGGCCACAACGACCTCTTCATCGCCGCCCACGCCTGCGCGTT
AGGTACCACACTGGTGACGGCCAACACGGCGGAGTTCGCCCGCATCGGGAAGCTGAAGGTCGAGAACTGGCTGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10125.55 Da        Isoelectric Point: 5.7425

>AT116065 WP_126060010.1 NZ_CP034446:623725-623994 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
MARHHRATPPKEAKLFRNNRSQAVRIPVEFELPGDKVLISREGDRLVIEPVRKSGLTALLAQWAKEPPLGPEDDFPEITD
RPVESEDIF

Download         Length: 270 bp

>AT116065 NZ_CP034446:623725-623994 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
ATGGCACGACACCACCGCGCAACGCCGCCGAAGGAAGCAAAACTATTCCGCAACAACCGCAGTCAGGCGGTGCGAATCCC
GGTCGAGTTTGAACTCCCTGGGGATAAGGTGCTGATCAGCCGCGAGGGCGACCGCCTCGTCATCGAGCCGGTCCGTAAAT
CAGGTCTCACGGCGTTGCTTGCCCAATGGGCGAAAGAACCTCCGCTCGGTCCTGAGGACGACTTCCCCGAGATCACGGAT
AGACCCGTCGAATCCGAGGACATTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References