Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6368222..6368834 Replicon chromosome
Accession NZ_CP034445
Organism Mesorhizobium sp. M2A.F.Ca.ET.043.02.1.1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EJ068_RS30705 Protein ID WP_126083820.1
Coordinates 6368649..6368834 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EJ068_RS30700 Protein ID WP_126082863.1
Coordinates 6368222..6368620 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ068_RS30675 6363822..6364880 + 1059 WP_128314819.1 glycerophosphodiester phosphodiesterase family protein -
EJ068_RS30680 6365087..6365959 - 873 WP_127250771.1 aldo/keto reductase family oxidoreductase -
EJ068_RS30685 6366055..6366960 + 906 WP_127250770.1 LysR family transcriptional regulator -
EJ068_RS30690 6367018..6367488 - 471 WP_040999876.1 30S ribosomal protein S9 -
EJ068_RS30695 6367488..6367952 - 465 WP_040983169.1 50S ribosomal protein L13 -
EJ068_RS30700 6368222..6368620 - 399 WP_126082863.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EJ068_RS30705 6368649..6368834 - 186 WP_126083820.1 type II toxin-antitoxin system HicA family toxin Toxin
EJ068_RS30710 6368879..6369334 - 456 WP_127250769.1 PaaI family thioesterase -
EJ068_RS30715 6369487..6370308 + 822 WP_127250768.1 enoyl-CoA hydratase -
EJ068_RS30720 6370353..6371135 + 783 WP_127250767.1 AAA family ATPase -
EJ068_RS30725 6371132..6371653 + 522 WP_127250766.1 CoA-binding protein -
EJ068_RS30730 6371814..6373094 + 1281 WP_129554969.1 O-acetylhomoserine aminocarboxypropyltransferase -
EJ068_RS30735 6373096..6373440 + 345 WP_127250764.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6953.13 Da        Isoelectric Point: 11.7888

>T116064 WP_126083820.1 NZ_CP034445:c6368834-6368649 [Mesorhizobium sp. M2A.F.Ca.ET.043.02.1.1]
IERDSRRIIKRLRDDGFELVSVRGSHHKFRKGAIVLVVPHPEKDLPVGTARAIAKQAGWIR

Download         Length: 186 bp

>T116064 NZ_CP034445:c6368834-6368649 [Mesorhizobium sp. M2A.F.Ca.ET.043.02.1.1]
ATCGAGCGTGACAGCCGCCGCATCATAAAGCGGCTGAGAGACGACGGCTTCGAATTGGTCTCAGTTCGGGGCTCGCATCA
CAAATTCCGAAAAGGCGCCATCGTGCTTGTCGTTCCGCACCCGGAAAAAGATCTGCCAGTCGGCACTGCTCGCGCGATCG
CCAAACAGGCAGGCTGGATTCGCTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14273.10 Da        Isoelectric Point: 4.4194

>AT116064 WP_126082863.1 NZ_CP034445:c6368620-6368222 [Mesorhizobium sp. M2A.F.Ca.ET.043.02.1.1]
MKNYFALVEKDADSAFGIRFPDIPGCFSAADVPEDIVPNAIEALQLWAEDMSVPEPSSHEAIVSLADIRTALSEGAYLVS
VPLIDNDSAVVRANVTFERGVLRAIDAAARERGITRSAFLSSAARREIEAKH

Download         Length: 399 bp

>AT116064 NZ_CP034445:c6368620-6368222 [Mesorhizobium sp. M2A.F.Ca.ET.043.02.1.1]
ATGAAGAACTACTTCGCGCTGGTTGAGAAGGATGCCGACAGCGCATTCGGTATTCGCTTCCCCGACATTCCGGGCTGTTT
TTCAGCGGCCGATGTACCCGAGGATATCGTGCCGAATGCAATCGAGGCCCTGCAACTTTGGGCCGAGGATATGTCCGTGC
CTGAACCATCCAGCCATGAGGCGATTGTATCGCTTGCCGATATCCGTACCGCGCTATCTGAAGGAGCTTATCTGGTCTCC
GTGCCGCTGATCGACAATGACAGTGCCGTGGTCAGGGCGAACGTGACATTCGAACGCGGTGTCCTGCGCGCAATCGATGC
CGCCGCGCGCGAGCGCGGCATCACTAGGTCCGCGTTTCTCTCAAGCGCCGCCCGCAGGGAAATTGAGGCAAAGCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References