Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB-HicA |
| Location | 5694336..5694930 | Replicon | chromosome |
| Accession | NZ_CP034443 | ||
| Organism | Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | EJ066_RS27605 | Protein ID | WP_126043092.1 |
| Coordinates | 5694336..5694524 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | EJ066_RS27610 | Protein ID | WP_126043093.1 |
| Coordinates | 5694529..5694930 (+) | Length | 134 a.a. |
Genomic Context
Location: 5694336..5694524 (189 bp)
Type: Toxin
Protein ID: WP_126043092.1
Type: Toxin
Protein ID: WP_126043092.1
Location: 5694529..5694930 (402 bp)
Type: Antitoxin
Protein ID: WP_126043093.1
Type: Antitoxin
Protein ID: WP_126043093.1
Location: 5695121..5695435 (315 bp)
Type: Others
Protein ID: WP_126043094.1
Type: Others
Protein ID: WP_126043094.1
Location: 5697842..5698465 (624 bp)
Type: Others
Protein ID: WP_126044074.1
Type: Others
Protein ID: WP_126044074.1
Location: 5691236..5691835 (600 bp)
Type: Others
Protein ID: WP_126043089.1
Type: Others
Protein ID: WP_126043089.1
Location: 5692200..5693189 (990 bp)
Type: Others
Protein ID: WP_126043090.1
Type: Others
Protein ID: WP_126043090.1
Location: 5693236..5694144 (909 bp)
Type: Others
Protein ID: WP_126043091.1
Type: Others
Protein ID: WP_126043091.1
Location: 5695658..5695981 (324 bp)
Type: Others
Protein ID: WP_126043095.1
Type: Others
Protein ID: WP_126043095.1
Location: 5695978..5697717 (1740 bp)
Type: Others
Protein ID: WP_126043096.1
Type: Others
Protein ID: WP_126043096.1
Location: 5698903..5699472 (570 bp)
Type: Others
Protein ID: WP_126043097.1
Type: Others
Protein ID: WP_126043097.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EJ066_RS27585 | 5691236..5691835 | - | 600 | WP_126043089.1 | hypothetical protein | - |
| EJ066_RS27595 | 5692200..5693189 | - | 990 | WP_126043090.1 | Coat protein | - |
| EJ066_RS27600 | 5693236..5694144 | - | 909 | WP_126043091.1 | hypothetical protein | - |
| EJ066_RS27605 | 5694336..5694524 | + | 189 | WP_126043092.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| EJ066_RS27610 | 5694529..5694930 | + | 402 | WP_126043093.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| EJ066_RS27615 | 5695121..5695435 | + | 315 | WP_126043094.1 | glycine zipper 2TM domain-containing protein | - |
| EJ066_RS27625 | 5695658..5695981 | - | 324 | WP_126043095.1 | hypothetical protein | - |
| EJ066_RS27630 | 5695978..5697717 | - | 1740 | WP_126043096.1 | phage tail protein | - |
| EJ066_RS27635 | 5697842..5698465 | + | 624 | WP_126044074.1 | methyltransferase domain-containing protein | - |
| EJ066_RS27640 | 5698903..5699472 | - | 570 | WP_126043097.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 5680890..5701776 | 20886 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 6993.16 Da Isoelectric Point: 11.4427
>T116059 WP_126043092.1 NZ_CP034443:5694336-5694524 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
MKSADVIDRLLADGWHEVARKGSHAQFKHKTKPGRVTVPHPRRDIPIGTLKSIEKQSGLKLR
MKSADVIDRLLADGWHEVARKGSHAQFKHKTKPGRVTVPHPRRDIPIGTLKSIEKQSGLKLR
Download Length: 189 bp
>T116059 NZ_CP034443:5694336-5694524 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
ATGAAGAGCGCCGATGTCATTGATAGATTGTTGGCGGATGGCTGGCACGAAGTGGCTCGAAAAGGCAGTCATGCCCAATT
CAAGCATAAGACCAAGCCGGGCCGCGTGACGGTTCCGCATCCCAGGCGAGACATCCCGATCGGCACGCTCAAGAGCATCG
AAAAGCAATCCGGCCTGAAGCTGAGGTAG
ATGAAGAGCGCCGATGTCATTGATAGATTGTTGGCGGATGGCTGGCACGAAGTGGCTCGAAAAGGCAGTCATGCCCAATT
CAAGCATAAGACCAAGCCGGGCCGCGTGACGGTTCCGCATCCCAGGCGAGACATCCCGATCGGCACGCTCAAGAGCATCG
AAAAGCAATCCGGCCTGAAGCTGAGGTAG
Antitoxin
Download Length: 134 a.a. Molecular weight: 14366.19 Da Isoelectric Point: 4.3857
>AT116059 WP_126043093.1 NZ_CP034443:5694529-5694930 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
MRHYIGLIHKEADSDFGVSFPDFPGVVTAGVNLDDARAMAEEALAFHVEGLVEDGEAIPEPSSLEEVMSDKDNLSGVAIL
VALKTEATKVVRVNVTIPEDVLNQIDHYAERHGYSRSGFLTAAAKKVMQIEAA
MRHYIGLIHKEADSDFGVSFPDFPGVVTAGVNLDDARAMAEEALAFHVEGLVEDGEAIPEPSSLEEVMSDKDNLSGVAIL
VALKTEATKVVRVNVTIPEDVLNQIDHYAERHGYSRSGFLTAAAKKVMQIEAA
Download Length: 402 bp
>AT116059 NZ_CP034443:5694529-5694930 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
ATGCGTCACTATATCGGACTGATCCACAAGGAAGCGGACAGCGACTTCGGCGTGTCCTTTCCCGATTTTCCGGGAGTGGT
CACGGCCGGCGTTAACCTGGACGACGCCCGCGCCATGGCGGAGGAAGCACTGGCCTTTCATGTCGAGGGCCTGGTCGAGG
ATGGCGAAGCCATTCCCGAACCGTCCTCCCTGGAGGAAGTGATGTCCGACAAGGACAATCTGAGCGGTGTCGCCATCCTG
GTTGCCTTGAAAACCGAAGCAACGAAGGTCGTGCGCGTCAACGTCACCATTCCGGAGGACGTCCTCAATCAAATCGACCA
CTATGCAGAACGCCACGGCTACAGCCGATCCGGATTTCTGACCGCCGCCGCGAAAAAGGTAATGCAGATCGAGGCGGCGT
AG
ATGCGTCACTATATCGGACTGATCCACAAGGAAGCGGACAGCGACTTCGGCGTGTCCTTTCCCGATTTTCCGGGAGTGGT
CACGGCCGGCGTTAACCTGGACGACGCCCGCGCCATGGCGGAGGAAGCACTGGCCTTTCATGTCGAGGGCCTGGTCGAGG
ATGGCGAAGCCATTCCCGAACCGTCCTCCCTGGAGGAAGTGATGTCCGACAAGGACAATCTGAGCGGTGTCGCCATCCTG
GTTGCCTTGAAAACCGAAGCAACGAAGGTCGTGCGCGTCAACGTCACCATTCCGGAGGACGTCCTCAATCAAATCGACCA
CTATGCAGAACGCCACGGCTACAGCCGATCCGGATTTCTGACCGCCGCCGCGAAAAAGGTAATGCAGATCGAGGCGGCGT
AG