Detailed information of TA system TA116059

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 5694336..5694930
• Replicon: chromosome
• Accession: NZ_CP034443
• Organism: Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EJ066_RS27605
• Protein ID: WP_126043092.1
• Coordinates: 5694336..5694524 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EJ066_RS27610
• Protein ID: WP_126043093.1
• Coordinates: 5694529..5694930 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJ066_RS27585	5691236..5691835	-	600	WP_126043089.1	hypothetical protein	-
EJ066_RS27595	5692200..5693189	-	990	WP_126043090.1	Coat protein	-
EJ066_RS27600	5693236..5694144	-	909	WP_126043091.1	hypothetical protein	-
EJ066_RS27605	5694336..5694524	+	189	WP_126043092.1	type II toxin-antitoxin system HicA family toxin	Toxin
EJ066_RS27610	5694529..5694930	+	402	WP_126043093.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EJ066_RS27615	5695121..5695435	+	315	WP_126043094.1	glycine zipper 2TM domain-containing protein	-
EJ066_RS27625	5695658..5695981	-	324	WP_126043095.1	hypothetical protein	-
EJ066_RS27630	5695978..5697717	-	1740	WP_126043096.1	phage tail protein	-
EJ066_RS27635	5697842..5698465	+	624	WP_126044074.1	methyltransferase domain-containing protein	-
EJ066_RS27640	5698903..5699472	-	570	WP_126043097.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	5680890..5701776	20886

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6993.16 Da
• Isoelectric Point: 11.4427

>T116059 WP_126043092.1 NZ_CP034443:5694336-5694524 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
MKSADVIDRLLADGWHEVARKGSHAQFKHKTKPGRVTVPHPRRDIPIGTLKSIEKQSGLKLR

Nucleotide

• Length: 189 bp

>T116059 NZ_CP034443:5694336-5694524 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
ATGAAGAGCGCCGATGTCATTGATAGATTGTTGGCGGATGGCTGGCACGAAGTGGCTCGAAAAGGCAGTCATGCCCAATT
CAAGCATAAGACCAAGCCGGGCCGCGTGACGGTTCCGCATCCCAGGCGAGACATCCCGATCGGCACGCTCAAGAGCATCG
AAAAGCAATCCGGCCTGAAGCTGAGGTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14366.19 Da
• Isoelectric Point: 4.3857

>AT116059 WP_126043093.1 NZ_CP034443:5694529-5694930 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
MRHYIGLIHKEADSDFGVSFPDFPGVVTAGVNLDDARAMAEEALAFHVEGLVEDGEAIPEPSSLEEVMSDKDNLSGVAIL
VALKTEATKVVRVNVTIPEDVLNQIDHYAERHGYSRSGFLTAAAKKVMQIEAA

Nucleotide

• Length: 402 bp

>AT116059 NZ_CP034443:5694529-5694930 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
ATGCGTCACTATATCGGACTGATCCACAAGGAAGCGGACAGCGACTTCGGCGTGTCCTTTCCCGATTTTCCGGGAGTGGT
CACGGCCGGCGTTAACCTGGACGACGCCCGCGCCATGGCGGAGGAAGCACTGGCCTTTCATGTCGAGGGCCTGGTCGAGG
ATGGCGAAGCCATTCCCGAACCGTCCTCCCTGGAGGAAGTGATGTCCGACAAGGACAATCTGAGCGGTGTCGCCATCCTG
GTTGCCTTGAAAACCGAAGCAACGAAGGTCGTGCGCGTCAACGTCACCATTCCGGAGGACGTCCTCAATCAAATCGACCA
CTATGCAGAACGCCACGGCTACAGCCGATCCGGATTTCTGACCGCCGCCGCGAAAAAGGTAATGCAGATCGAGGCGGCGT
AG