Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 5615932..5616602 Replicon chromosome
Accession NZ_CP034443
Organism Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EJ066_RS27170 Protein ID WP_126043011.1
Coordinates 5615932..5616330 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJ066_RS27175 Protein ID WP_126043012.1
Coordinates 5616330..5616602 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ066_RS27150 5612073..5613101 + 1029 WP_126043007.1 sulfate ABC transporter substrate-binding protein -
EJ066_RS27155 5613134..5613985 + 852 WP_126043008.1 sulfate ABC transporter permease subunit CysT -
EJ066_RS27160 5613978..5614862 + 885 WP_126043009.1 sulfate ABC transporter permease subunit CysW -
EJ066_RS27165 5614875..5615915 + 1041 WP_126043010.1 sulfate/molybdate ABC transporter ATP-binding protein -
EJ066_RS27170 5615932..5616330 - 399 WP_126043011.1 type II toxin-antitoxin system VapC family toxin Toxin
EJ066_RS27175 5616330..5616602 - 273 WP_126043012.1 antitoxin Antitoxin
EJ066_RS27180 5616837..5617823 + 987 WP_126043013.1 sulfate ABC transporter substrate-binding protein -
EJ066_RS27185 5618075..5618524 + 450 WP_126043014.1 Rrf2 family transcriptional regulator -
EJ066_RS27190 5618521..5619006 - 486 WP_126044064.1 gluconokinase -
EJ066_RS27195 5619078..5620064 - 987 WP_126043015.1 ABC transporter permease -
EJ066_RS27200 5620061..5621041 - 981 WP_126043016.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(17-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14126.42 Da        Isoelectric Point: 5.7385

>T116058 WP_126043011.1 NZ_CP034443:c5616330-5615932 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
MRFMLDTNIISDMIRNPAGKAASAMVREGDAAVCTSIVVASELRYGCARKGSAKLLKKVEELLAEIPVLPLDVPVDTEYG
ALRTELEGAGQTIGHNDLFIAAHACALGITLVTANTGEFNRIKGLKIENWLA

Download         Length: 399 bp

>T116058 NZ_CP034443:c5616330-5615932 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
ATGCGGTTCATGCTGGACACGAACATTATCAGCGACATGATCCGAAACCCGGCTGGCAAAGCAGCAAGTGCAATGGTGCG
CGAGGGAGACGCCGCCGTGTGCACCAGCATCGTGGTCGCCTCGGAACTGCGATATGGCTGCGCCAGGAAGGGATCGGCCA
AGCTGCTTAAGAAAGTCGAGGAGCTGCTGGCTGAGATCCCTGTTTTGCCGCTCGATGTGCCGGTAGATACCGAGTACGGC
GCACTTCGCACCGAGCTGGAAGGCGCGGGCCAGACCATTGGCCACAATGACCTTTTTATTGCTGCCCACGCCTGCGCACT
GGGCATTACGCTGGTGACGGCCAACACGGGAGAATTCAACCGGATCAAGGGCTTGAAGATCGAGAACTGGCTAGCATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10206.70 Da        Isoelectric Point: 4.8952

>AT116058 WP_126043012.1 NZ_CP034443:c5616602-5616330 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
MPQRRHSTPPPKEAKLFRNNRSQAVRIPVEFELPGEKVLISREGDRLVIEPVRKPGLTALLAQWAKEPPLGPEDDFPEID
DAPIESVEIF

Download         Length: 273 bp

>AT116058 NZ_CP034443:c5616602-5616330 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
ATGCCCCAGCGCCGCCATTCAACCCCGCCACCGAAGGAGGCGAAGCTGTTCCGCAACAACCGCAGCCAGGCGGTGCGCAT
TCCCGTCGAGTTCGAGCTTCCCGGCGAAAAGGTCTTGATCAGCCGTGAAGGCGACCGCCTGGTCATCGAGCCGGTCCGCA
AACCTGGCCTCACAGCGCTGCTCGCCCAATGGGCGAAAGAGCCGCCGCTCGGTCCTGAAGACGACTTCCCGGAGATCGAC
GATGCGCCTATCGAATCCGTGGAAATTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References