Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 221510..222138 Replicon chromosome
Accession NZ_CP034443
Organism Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EJ066_RS01145 Protein ID WP_126034431.1
Coordinates 221510..221896 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJ066_RS01150 Protein ID WP_126034432.1
Coordinates 221893..222138 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ066_RS01130 217021..218112 + 1092 WP_126034428.1 succinylglutamate desuccinylase/aspartoacylase family protein -
EJ066_RS01135 218361..220550 + 2190 WP_126034429.1 anthranilate synthase -
EJ066_RS01140 220556..221503 + 948 WP_126034430.1 cation diffusion facilitator family transporter -
EJ066_RS01145 221510..221896 - 387 WP_126034431.1 type II toxin-antitoxin system VapC family toxin Toxin
EJ066_RS01150 221893..222138 - 246 WP_126034432.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EJ066_RS01155 222215..223288 - 1074 WP_126034433.1 hypothetical protein -
EJ066_RS01160 223386..223823 + 438 WP_126034434.1 DsrE family protein -
EJ066_RS01165 223892..224692 + 801 WP_126034435.1 SDR family oxidoreductase -
EJ066_RS01170 224739..225047 + 309 WP_126034436.1 antibiotic biosynthesis monooxygenase -
EJ066_RS01175 225120..226208 + 1089 WP_126034437.1 AbrB family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14381.43 Da        Isoelectric Point: 8.4337

>T116053 WP_126034431.1 NZ_CP034443:c221896-221510 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
VIYLLDTNAVIAIMKGDADLQARLKPYRPQDFALSAIVVHELYYGAQKSQRKADNLARIEALQFPVLEFDREDARHAGEI
RATLATSGTPIGPYDALIGGQARARNLTLITRNAREFERIKNLTIETW

Download         Length: 387 bp

>T116053 NZ_CP034443:c221896-221510 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
GTGATCTATCTGCTCGACACCAATGCGGTCATCGCGATCATGAAAGGTGACGCAGATCTGCAGGCACGGCTCAAGCCATA
CAGGCCGCAGGATTTCGCACTTTCGGCCATTGTCGTGCACGAACTCTACTACGGTGCTCAAAAGAGCCAGCGAAAGGCCG
ACAATCTGGCGCGCATCGAAGCGCTCCAGTTCCCGGTACTCGAATTCGATCGGGAAGATGCAAGGCATGCCGGCGAGATT
CGGGCGACGCTTGCGACGTCAGGGACCCCGATTGGTCCCTATGATGCGCTGATTGGTGGGCAGGCGCGGGCCCGGAACCT
CACGCTGATAACCCGCAATGCACGGGAATTCGAGCGGATCAAAAACCTCACAATCGAGACCTGGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9382.58 Da        Isoelectric Point: 4.5257

>AT116053 WP_126034432.1 NZ_CP034443:c222138-221893 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
MEKAKVFWSGRSQAVRLPKEFRFETDEVSIRRHGQSIILEPLAKDWAWLDQVIGPLDDDFAEAALERPAEQDRPALDDVF
K

Download         Length: 246 bp

>AT116053 NZ_CP034443:c222138-221893 [Mesorhizobium sp. M9A.F.Ca.ET.002.03.1.2]
ATGGAAAAAGCAAAGGTGTTCTGGTCAGGCCGCTCGCAGGCGGTGCGGCTGCCAAAGGAATTCCGTTTCGAAACCGATGA
GGTTTCGATTCGCCGCCATGGCCAGAGTATAATCCTCGAACCGCTCGCGAAGGACTGGGCCTGGCTCGACCAGGTGATAG
GTCCGCTTGACGATGATTTCGCCGAGGCAGCACTGGAACGTCCAGCTGAGCAGGACCGGCCGGCTTTGGATGACGTTTTC
AAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References