Detailed information of TA system TA116052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-HTH_XRE
• Location: 1141042..1142285
• Replicon: chromosome
• Accession: NZ_CP034442
• Organism: Streptococcus oralis subsp. dentisani strain F0392

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: F9P308
• Locus tag: EJF26_RS05730
• Protein ID: WP_000762940.1
• Coordinates: 1141042..1141809 (-)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: EJF26_RS05735
• Protein ID: WP_000578854.1
• Coordinates: 1141809..1142285 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJF26_RS05715	1136754..1137392	-	639	WP_000944642.1	phosphate uptake regulator PhoU	-
EJF26_RS05720	1137475..1138206	-	732	WP_000687248.1	protein phosphatase 2C domain-containing protein	-
EJF26_RS05725	1138193..1140421	-	2229	WP_000680277.1	right-handed parallel beta-helix repeat-containing protein	-
EJF26_RS05730	1141042..1141809	-	768	WP_000762940.1	zeta toxin family protein	Toxin
EJF26_RS05735	1141809..1142285	-	477	WP_000578854.1	helix-turn-helix domain-containing protein	Antitoxin
EJF26_RS05740	1142503..1142865	-	363	WP_000479226.1	hypothetical protein	-
EJF26_RS05745	1143871..1144881	+	1011	WP_001085615.1	site-specific integrase	-
EJF26_RS05750	1145283..1146626	+	1344	WP_000842031.1	hypothetical protein	-
EJF26_RS05755	1146762..1147022	+	261	WP_001048148.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 29265.30 Da
• Isoelectric Point: 7.2204

>T116052 WP_000762940.1 NZ_CP034442:c1141809-1141042 [Streptococcus oralis subsp. dentisani]
MKLEEFSQDNFEQASKRLIRSLTRGKTTSSHPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPRKTAQLLATRGYQVSLALIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELETAKLFRQIQIYQRDQSCVYNSEVDQISAAEVLHECLFGKWNKVEKEML
KIEQERLRELGEIDK

Nucleotide

• Length: 768 bp

>T116052 NZ_CP034442:c1141809-1141042 [Streptococcus oralis subsp. dentisani]
ATGAAACTAGAAGAATTTAGTCAAGATAATTTTGAACAAGCCTCCAAACGGCTTATCCGTTCTTTAACTCGTGGAAAAAC
AACCTCATCTCATCCTAAGGCTATTTTGCTCGGTGGACAGAGTGGTGCTGGGAAAACAACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGTAATATCATTATCATTGATGGGGATAGTTATCGCTCTTTTCATCCGAACTACCTTGGCCTACAGGAA
AAGTATGGCAAAGATAGTGTGGATTATACAAAAGTATTCGCGGGACAAATGGTTGAATATCTTGTAGATGAGTTGAGTAA
AAAAGGTTATCATTTATTAATCGAGGGTACCTTGAGAACAACAGAAGTTCCCCGAAAAACGGCCCAATTATTGGCAACTA
GAGGATATCAAGTCTCACTTGCACTGATTGCGACCAAGCCAGAATTGTCTTATCTCAGTACCTTGATACGTTATGAGGAG
CTCCATGCTATAGACCCTAGTCAAGCAAGAGCGACTCCCAAAGAGCACCATGACGGAATTGTAGAACATTTAGTTGATAA
CTTACGAGAGTTGGAAACGGCTAAACTTTTTAGACAAATTCAAATTTATCAAAGAGATCAATCGTGTGTTTATAATTCGG
AAGTAGATCAAATCTCAGCAGCAGAAGTTCTACACGAATGCCTATTTGGAAAATGGAACAAGGTGGAAAAAGAGATGTTG
AAGATAGAGCAGGAACGGTTGAGAGAGTTGGGGGAAATTGATAAGTGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18234.87 Da
• Isoelectric Point: 4.7437

>AT116052 WP_000578854.1 NZ_CP034442:c1142285-1141809 [Streptococcus oralis subsp. dentisani]
MIGENIKTLRKTHKLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTLNPWVLMSDDLSDLINTRIYLVSTFEDIERFNGYLDGIERMLEQATHLVVA

Nucleotide

• Length: 477 bp

>AT116052 NZ_CP034442:c1142285-1141809 [Streptococcus oralis subsp. dentisani]
ATGATTGGAGAAAATATAAAAACGTTACGTAAAACACATAAATTAACGCAGCCTGAGTTTGCAAAGATTGTTGGTATCTC
TAGAAATAGTCTGAGTCGTTATGAAAATGGGACAAGTCGAGTTTCGACAGAATTAATAGATCGTATCTGCAAGAAATTTA
ATGTTTCGTATATCGATATCGTAGGGGAGGAAAAAATGCTCACACCAGTAGAAGATTATCAATTAACTCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTTCAAGATGAACAAGGAATTGCATTTGATGATAC
TTTAAATCCTTGGGTTCTAATGAGCGATGATTTGTCTGATTTGATTAATACGAGGATTTATCTTGTTTCAACTTTTGAGG
ATATAGAGCGATTTAATGGCTATTTGGATGGTATTGAACGTATGCTAGAACAAGCTACTCATCTGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A1X1GZB7