Detailed information of TA system TA116051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 528481..529718
• Replicon: chromosome
• Accession: NZ_CP034442
• Organism: Streptococcus oralis subsp. dentisani strain F0392

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: F9P0Y1
• Locus tag: EJF26_RS02775
• Protein ID: WP_000512671.1
• Coordinates: 528481..529242 (-)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: EJF26_RS02780
• Protein ID: WP_000579595.1
• Coordinates: 529242..529718 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJF26_RS02755	524296..524661	-	366	WP_000263057.1	MobC family plasmid mobilization relaxosome protein	-
EJF26_RS02760	524671..525030	-	360	WP_000529548.1	hypothetical protein	-
EJF26_RS02765	525954..526697	-	744	WP_080563309.1	hypothetical protein	-
EJF26_RS02770	526894..528168	-	1275	Protein_524	AAA family ATPase	-
EJF26_RS02775	528481..529242	-	762	WP_000512671.1	zeta toxin family protein	Toxin
EJF26_RS02780	529242..529718	-	477	WP_000579595.1	helix-turn-helix domain-containing protein	Antitoxin
EJF26_RS02785	529788..530060	-	273	WP_000495447.1	hypothetical protein	-
EJF26_RS02790	530097..530480	-	384	WP_000159218.1	hypothetical protein	-
EJF26_RS02795	530477..530710	-	234	WP_000152426.1	hypothetical protein	-
EJF26_RS02800	530761..531846	-	1086	WP_000401894.1	toprim domain-containing protein	-
EJF26_RS02805	531856..532497	-	642	WP_000933089.1	hypothetical protein	-
EJF26_RS02810	532657..532854	+	198	WP_004246112.1	hypothetical protein	-
EJF26_RS02815	532868..533164	-	297	WP_000998892.1	hypothetical protein	-
EJF26_RS02820	533178..533462	-	285	WP_000969635.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	429066..536485	107419

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (24-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 28904.86 Da
• Isoelectric Point: 6.9215

>T116051 WP_000512671.1 NZ_CP034442:c529242-528481 [Streptococcus oralis subsp. dentisani]
MGIQDYTDSQFKQALARNIRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
AYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKETAQHLKSKGYEVQLAIIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTAPAADILQELLFGEWSQVEKEML
KVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T116051 NZ_CP034442:c529242-528481 [Streptococcus oralis subsp. dentisani]
ATGGGAATCCAAGATTATACCGATAGTCAATTTAAACAGGCTTTAGCAAGGAACATTCGCTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTACTTGGAGGGCAAAGTGGTGCTGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GCATATGGCAAAGATAGTGTTGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACCGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACAATTGATGTTCCAAAGGAAACAGCACAACACTTGAAAAGTA
AGGGATATGAAGTACAATTAGCCATAATCGCAACAAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
TTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAGCTCCAGCAGCAGATATTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAGGTAGAGAAAGAGATGTTG
AAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18229.69 Da
• Isoelectric Point: 4.4977

>AT116051 WP_000579595.1 NZ_CP034442:c529718-529242 [Streptococcus oralis subsp. dentisani]
MIGKNIKSLRKSHDLTQPEFARIIGISRNSLSRYENGSSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGAILLSRLYRYQDSQGIRVDDESNPWVLMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMAA

Nucleotide

• Length: 477 bp

>AT116051 NZ_CP034442:c529718-529242 [Streptococcus oralis subsp. dentisani]
ATGATTGGAAAGAACATAAAATCCTTACGTAAATCACATGACTTAACACAACCTGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGTTTGAGTCGTTATGAAAATGGCTCTAGTTCAGTCTCTACGGAACTAATAGATATCATCTGCCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTATTCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGAGTTGATGATGA
ATCTAATCCTTGGGTTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGCAGCCTAA

Structures

Toxin

• AlphaFold DB: F9P0Y1