Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2064478..2064992 Replicon chromosome
Accession NZ_CP034441
Organism Staphylococcus aureus strain PMB 81-4

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag EJN89_RS10600 Protein ID WP_000581793.1
Coordinates 2064783..2064992 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag EJN89_RS10595 Protein ID WP_000138932.1
Coordinates 2064478..2064771 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN89_RS10565 2059940..2060581 + 642 WP_000483155.1 thiamine phosphate synthase -
EJN89_RS10570 2060667..2061539 + 873 WP_000725802.1 membrane protein insertase YidC -
EJN89_RS10585 2062153..2062800 - 648 WP_001187628.1 HD domain-containing protein -
EJN89_RS10590 2062828..2064312 - 1485 WP_000571549.1 cardiolipin synthase -
EJN89_RS10595 2064478..2064771 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
EJN89_RS10600 2064783..2064992 + 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
EJN89_RS10605 2065120..2065257 + 138 WP_000828354.1 hypothetical protein -
EJN89_RS10610 2065520..2066722 - 1203 WP_001109939.1 rod shape-determining protein RodA -
EJN89_RS10615 2067040..2068110 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
EJN89_RS10620 2068125..2069483 + 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T116043 WP_000581793.1 NZ_CP034441:2064783-2064992 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T116043 NZ_CP034441:2064783-2064992 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT116043 WP_000138932.1 NZ_CP034441:2064478-2064771 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT116043 NZ_CP034441:2064478-2064771 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References