Detailed information of TA system TA116030

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 6346765..6347391
• Replicon: chromosome
• Accession: NZ_CP034437
• Organism: Paenibacillus albus strain 18JY67-1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: EJC50_RS28695
• Protein ID: WP_090581240.1
• Coordinates: 6346765..6347115 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: EJC50_RS28700
• Protein ID: WP_178075161.1
• Coordinates: 6347119..6347391 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJC50_RS28680	6343171..6345051	-	1881	WP_126019574.1	sensor histidine kinase	-
EJC50_RS28685	6345223..6345897	-	675	WP_126019576.1	hypothetical protein	-
EJC50_RS28690	6345908..6346600	-	693	WP_126019578.1	hypothetical protein	-
EJC50_RS28695	6346765..6347115	-	351	WP_090581240.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
EJC50_RS28700	6347119..6347391	-	273	WP_178075161.1	ribbon-helix-helix protein, CopG family	Antitoxin
EJC50_RS28705	6347639..6348823	-	1185	WP_126019581.1	alanine racemase	-
EJC50_RS28710	6348989..6350302	-	1314	WP_126019583.1	DUF4367 domain-containing protein	-
EJC50_RS28715	6350477..6351451	-	975	WP_126019585.1	undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-110)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12832.80 Da
• Isoelectric Point: 5.1284

>T116030 WP_090581240.1 NZ_CP034437:c6347115-6346765 [Paenibacillus albus]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAALHGFDRDSVLLLEQI
RTIDKQRLTDKITHLDDETMRKVDEALQISVGLIDF

Nucleotide

• Length: 351 bp

>T116030 NZ_CP034437:c6347115-6346765 [Paenibacillus albus]
TTGATCGTTAAACGCGGCGATGTGTTTTTTGCTGATTTGTCACCTGTTGTCGGTTCTGAACAGGGAGGAGTGCGTCCTGT
TCTCGTTATTCAAAATGATATTGGCAACCGCTTTAGTCCAACCGTCATTGTAGCTGCGATTACAGCTCAAATACAGAAGG
CTAAGCTGCCGACGCATGTAGAGATTGATGCGGCGCTTCATGGGTTTGACCGTGATTCCGTCCTTCTTCTCGAACAGATT
CGCACGATTGATAAACAGCGTCTTACCGACAAGATCACACACCTCGACGATGAAACGATGCGCAAAGTAGACGAGGCGCT
GCAGATCAGCGTTGGCCTTATTGATTTTTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10354.95 Da
• Isoelectric Point: 7.0150

>AT116030 WP_178075161.1 NZ_CP034437:c6347391-6347119 [Paenibacillus albus]
MQNTKRIMISLPDHLLEEVDGIVARENSNRSEFIRQAMKLYLIERKKRQIRDSMQRGYLEMAKINLVMASEAFQAEEDAG
DTLGRLVSGV

Nucleotide

• Length: 273 bp

>AT116030 NZ_CP034437:c6347391-6347119 [Paenibacillus albus]
ATGCAAAACACCAAAAGGATTATGATCAGCTTACCGGATCATTTGCTGGAGGAAGTCGACGGAATCGTCGCCAGAGAAAA
CTCGAACCGGAGCGAATTTATTCGTCAGGCAATGAAATTGTACTTGATTGAACGGAAGAAACGTCAGATTCGCGATTCGA
TGCAGCGCGGCTATTTGGAAATGGCCAAAATCAACTTAGTGATGGCGTCGGAAGCTTTTCAAGCGGAGGAAGATGCCGGC
GATACGCTCGGCCGACTCGTAAGCGGGGTGTAA