116028

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6095685..6096190 Replicon chromosome
Accession NZ_CP034436
Organism Pseudomonas aeruginosa strain B17932

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag EJP73_RS28965 Protein ID WP_031640969.1
Coordinates 6095909..6096190 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EJP73_RS28960 Protein ID WP_003083775.1
Coordinates 6095685..6095912 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJP73_RS28935 6090704..6092197 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
EJP73_RS28940 6092366..6093793 + 1428 WP_003083784.1 GABA permease -
EJP73_RS28945 6093875..6094216 - 342 WP_003101229.1 alkylphosphonate utilization protein -
EJP73_RS28950 6094288..6094788 - 501 WP_003101228.1 LEA type 2 family protein -
EJP73_RS28955 6094889..6095509 + 621 WP_003101226.1 hypothetical protein -
EJP73_RS28960 6095685..6095912 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EJP73_RS28965 6095909..6096190 + 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
EJP73_RS28970 6096490..6097398 + 909 WP_033990895.1 LysR family transcriptional regulator -
EJP73_RS28975 6097430..6097816 - 387 WP_003083767.1 aegerolysin family protein -
EJP73_RS28980 6098020..6098754 - 735 WP_003128333.1 GntR family transcriptional regulator -
EJP73_RS28985 6098855..6099541 - 687 WP_003083762.1 FadR family transcriptional regulator -
EJP73_RS28990 6099590..6100939 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T116028 WP_031640969.1 NZ_CP034436:6095909-6096190 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T116028 NZ_CP034436:6095909-6096190 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGAACCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT116028 WP_003083775.1 NZ_CP034436:6095685-6095912 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT116028 NZ_CP034436:6095685-6095912 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References