Detailed information of TA system TA116021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 3822805..3823284
• Replicon: chromosome
• Accession: NZ_CP034433
• Organism: Iodobacter sp. H11R3

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: EJO50_RS17310
• Protein ID: WP_206434543.1
• Coordinates: 3823141..3823284 (+)
• Length: 48 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: EJO50_RS16860
• Protein ID: WP_125976119.1
• Coordinates: 3822805..3823029 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJO50_RS16840	3819448..3820140	+	693	WP_125976113.1	hypothetical protein	-
EJO50_RS16845	3820155..3820694	+	540	WP_125976115.1	hypothetical protein	-
EJO50_RS16850	3821344..3821898	+	555	WP_125976117.1	hypothetical protein	-
EJO50_RS16855	3822237..3822629	-	393	WP_206434416.1	hypothetical protein	-
EJO50_RS16860	3822805..3823029	+	225	WP_125976119.1	TraY domain-containing protein	Antitoxin
EJO50_RS17310	3823141..3823284	+	144	WP_206434543.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EJO50_RS16870	3823597..3824683	-	1087	Protein_3283	IS3 family transposase	-
EJO50_RS16875	3825067..3826860	+	1794	WP_125976121.1	CBS domain-containing protein	-
EJO50_RS16880	3826857..3827480	+	624	WP_125976123.1	3'-5' exonuclease	-
EJO50_RS16885	3827445..3828128	-	684	WP_125976125.1	SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3824417..3824683	266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-46)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5369.21 Da
• Isoelectric Point: 10.0389

>T116021 WP_206434543.1 NZ_CP034433:3823141-3823284 [Iodobacter sp. H11R3]
IGEALKGSQLGEFWKYRVGDYRLISSIEDGALRILVVKIGNRREAYK

Nucleotide

• Length: 144 bp

>T116021 NZ_CP034433:3823141-3823284 [Iodobacter sp. H11R3]
ATTGGAGAAGCACTTAAAGGCTCTCAATTAGGGGAGTTCTGGAAGTACCGTGTGGGTGATTACCGACTTATCAGCAGCAT
AGAAGATGGGGCCTTACGCATCCTCGTTGTGAAAATAGGTAATCGACGAGAAGCGTACAAATAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8520.82 Da
• Isoelectric Point: 4.6128

>AT116021 WP_125976119.1 NZ_CP034433:3822805-3823029 [Iodobacter sp. H11R3]
MLAIRLPAEIENRLDVLAKSTGRTKTFYAKEAILQHLDDLEDLYLAEQRLKDIQEGRTKTIPLEEVMMNYGLEG

Nucleotide

• Length: 225 bp

>AT116021 NZ_CP034433:3822805-3823029 [Iodobacter sp. H11R3]
ATGTTAGCAATTCGCTTACCGGCTGAAATTGAAAACCGCTTAGACGTCTTGGCCAAGTCGACAGGCAGAACTAAAACTTT
TTATGCAAAAGAAGCAATTCTTCAGCACTTGGATGATCTAGAAGATCTATACCTAGCCGAACAACGCTTAAAAGATATTC
AAGAAGGACGGACTAAAACCATTCCCCTTGAAGAAGTCATGATGAACTATGGCTTGGAAGGTTGA