Detailed information of TA system TA116020

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 654923..655400
• Replicon: chromosome
• Accession: NZ_CP034433
• Organism: Iodobacter sp. H11R3

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: EJO50_RS02840
• Protein ID: WP_125971483.1
• Coordinates: 654923..655192 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: EJO50_RS02845
• Protein ID: WP_125971484.1
• Coordinates: 655176..655400 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJO50_RS02805	650580..650819	-	240	WP_125971476.1	hypothetical protein	-
EJO50_RS02810	650907..652817	-	1911	WP_125971477.1	replication endonuclease	-
EJO50_RS02815	652814..653272	-	459	WP_125971478.1	hypothetical protein	-
EJO50_RS02825	653718..653954	-	237	WP_125971480.1	hypothetical protein	-
EJO50_RS02830	654041..654514	+	474	WP_125971481.1	helix-turn-helix transcriptional regulator	-
EJO50_RS02835	654614..654868	+	255	WP_125971482.1	hypothetical protein	-
EJO50_RS02840	654923..655192	-	270	WP_125971483.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EJO50_RS02845	655176..655400	-	225	WP_125971484.1	TraY domain-containing protein	Antitoxin
EJO50_RS02850	655638..655973	-	336	WP_125971485.1	helix-turn-helix domain-containing protein	-
EJO50_RS02855	655970..656314	-	345	WP_125971486.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EJO50_RS02860	656414..657469	-	1056	WP_125971487.1	phage late control D family protein	-
EJO50_RS02865	657466..657876	-	411	WP_125971488.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	645276..704166	58890

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10231.93 Da
• Isoelectric Point: 10.0935

>T116020 WP_125971483.1 NZ_CP034433:c655192-654923 [Iodobacter sp. H11R3]
MAWLIKLDEEAQKDLAKLDKQVARRITAFLRDRVATLEDPRSIGEALKGSKLGEFWKYPVGDYRLISSIEDGALRILVVK
IGNRREVYK

Nucleotide

• Length: 270 bp

>T116020 NZ_CP034433:c655192-654923 [Iodobacter sp. H11R3]
TTGGCCTGGCTGATTAAACTGGATGAAGAAGCTCAGAAAGATCTAGCCAAGCTAGATAAGCAAGTAGCACGAAGGATTAC
AGCTTTTTTACGGGATCGGGTCGCAACGCTAGAAGACCCACGCAGCATAGGCGAGGCCTTAAAAGGCTCTAAGCTGGGCG
AATTCTGGAAGTACCCTGTGGGTGATTACCGACTTATCAGCAGCATAGAAGATGGAGCCTTGCGCATCCTCGTTGTGAAA
ATAGGTAATCGACGTGAAGTGTACAAATAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8467.64 Da
• Isoelectric Point: 4.7815

>AT116020 WP_125971484.1 NZ_CP034433:c655400-655176 [Iodobacter sp. H11R3]
MLAIRLPAEIESRLDFLAKSTGRTKTFYAREAIIQHLDDLEDLYLAEQRLLAIRSGQSKTYSLEEVERNLGLAD

Nucleotide

• Length: 225 bp

>AT116020 NZ_CP034433:c655400-655176 [Iodobacter sp. H11R3]
ATGTTAGCAATCAGACTGCCTGCCGAGATCGAAAGCCGCTTAGACTTTTTAGCGAAGAGTACCGGCAGGACTAAAACATT
TTACGCCAGAGAGGCAATTATTCAGCACTTGGATGATTTAGAAGACCTCTATCTGGCCGAACAGCGCTTGTTAGCTATCC
GCTCTGGGCAAAGTAAAACCTATAGCTTAGAAGAAGTGGAGCGCAATCTTGGCCTGGCTGATTAA