Detailed information of TA system TA116019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3508..4040
• Replicon: chromosome
• Accession: NZ_CP034433
• Organism: Iodobacter sp. H11R3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EJO50_RS00035
• Protein ID: WP_206434420.1
• Coordinates: 3738..4040 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EJO50_RS00030
• Protein ID: WP_125970994.1
• Coordinates: 3508..3741 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJO50_RS00010	535..1629	-	1095	WP_125970991.1	hypothetical protein	-
EJO50_RS00015	2235..2672	+	438	WP_206434419.1	PACE efflux transporter	-
EJO50_RS00020	2712..3185	+	474	WP_125970992.1	WbuC family cupin fold metalloprotein	-
EJO50_RS00025	3167..3373	-	207	WP_125970993.1	hypothetical protein	-
EJO50_RS00030	3508..3741	+	234	WP_125970994.1	hypothetical protein	Antitoxin
EJO50_RS00035	3738..4040	+	303	WP_206434420.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EJO50_RS00040	4080..6863	+	2784	WP_125970995.1	class I SAM-dependent DNA methyltransferase	-
EJO50_RS00045	6860..7648	+	789	WP_125970996.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-95)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11545.40 Da
• Isoelectric Point: 10.4958

>T116019 WP_206434420.1 NZ_CP034433:3738-4040 [Iodobacter sp. H11R3]
MNYTHSLRPRWLRQAIANLDAEAEYIAQEKPQAAAEMFAYVKAKVESLAHFPAAGRPGRVPGTRELVIERYPLLVPYRVV
GNELHVLRVFHTRRKPPLNW

Nucleotide

• Length: 303 bp

>T116019 NZ_CP034433:3738-4040 [Iodobacter sp. H11R3]
TTGAATTATACCCATAGCCTGCGGCCTAGGTGGCTACGTCAAGCTATCGCCAATCTGGATGCCGAGGCGGAATATATCGC
TCAGGAAAAACCACAGGCCGCAGCTGAAATGTTTGCCTATGTGAAAGCCAAAGTTGAAAGCTTGGCTCATTTTCCCGCTG
CGGGCAGGCCGGGGCGCGTACCCGGCACGCGCGAGCTAGTCATCGAACGCTACCCCTTGCTCGTACCCTATCGTGTAGTG
GGTAATGAACTACATGTGCTCAGGGTATTTCACACTCGCCGTAAGCCGCCGCTCAACTGGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8400.51 Da
• Isoelectric Point: 4.2110

>AT116019 WP_125970994.1 NZ_CP034433:3508-3741 [Iodobacter sp. H11R3]
MSMMSMRLPDELSQQLEALAVATGRTKSYLAGQAIRAFVEQEAWQIKEIKAALQEADAGDFASDEEVAALSAKWQAP

Nucleotide

• Length: 234 bp

>AT116019 NZ_CP034433:3508-3741 [Iodobacter sp. H11R3]
ATGAGCATGATGTCAATGCGTCTGCCGGATGAATTAAGCCAGCAGCTGGAAGCGCTGGCCGTGGCGACCGGGCGGACTAA
ATCTTATCTGGCCGGGCAGGCTATCCGGGCTTTTGTTGAACAGGAAGCCTGGCAGATCAAGGAAATTAAAGCTGCGCTGC
AAGAGGCCGATGCGGGTGATTTTGCCAGTGACGAGGAAGTGGCTGCGCTAAGCGCAAAGTGGCAGGCTCCTTGA