Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 8126101..8127584 Replicon chromosome
Accession NZ_CP034432
Organism Bradyrhizobium sp. LCT2

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag EI171_RS38375 Protein ID WP_161536359.1
Coordinates 8126325..8127584 (+) Length 420 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag EI171_RS38370 Protein ID WP_161536358.1
Coordinates 8126101..8126328 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EI171_RS38350 8121424..8121678 - 255 Protein_7530 transposase -
EI171_RS38360 8123651..8124637 - 987 WP_161536356.1 RelA/SpoT domain-containing protein -
EI171_RS38365 8124637..8125716 - 1080 WP_161536357.1 nucleoid-associated protein -
EI171_RS38370 8126101..8126328 + 228 WP_161536358.1 type II toxin-antitoxin system Y4mF family antitoxin Antitoxin
EI171_RS38375 8126325..8127584 + 1260 WP_161536359.1 HipA domain-containing protein Toxin
EI171_RS38380 8127770..8128288 - 519 WP_161536360.1 hypothetical protein -
EI171_RS38385 8128689..8129015 - 327 WP_161537153.1 N-formylglutamate amidohydrolase -
EI171_RS38390 8130002..8130208 + 207 WP_161536361.1 cold-shock protein -
EI171_RS38395 8130699..8131223 + 525 WP_161536362.1 MarR family transcriptional regulator -
EI171_RS38400 8131503..8131688 - 186 Protein_7540 acyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 8116628..8140364 23736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Transcription regulator, HipB-like

(9-64)


Sequences

Toxin        


Download         Length: 420 a.a.        Molecular weight: 45379.04 Da        Isoelectric Point: 6.0658

>T116018 WP_161536359.1 NZ_CP034432:8126325-8127584 [Bradyrhizobium sp. LCT2]
MNHLLDVYFGSVKAGILNQDDAGMLSYSYDTGYLAGGAARAISFSMPLQEAPHPDRIVRPFFSGLLPDEGARQRLAGALG
ISAGNAFGLLEVIGGECAGALSLYPAGQAPPSSDDDGVEVLTPARLEEILGKLRERPLLGGEEGVRLSLAGVQDKLAVCL
EGERIGLAKGGRPTTHILKPFIQALEGSVENELFCLRLAALLTLPVPDVQMRRQGAISYLLVERYDRSRDNDGTISRLHQ
EDFCQALSVPPELKYEEEGGPGTERSLDLIGRATARPAADRLSFIRMLIFHYLVGNADAHGKNYALLYRGEVPDLAPLYD
VVCTAAYQRLAKKLAMAIGGRSVPDTIQLQHWLTLVPATRGAQRLLIKDIKESADRIRSAADGLLTELEEAGVTHAILKT
IRTVIETRASHLLRITEKA

Download         Length: 1260 bp

>T116018 NZ_CP034432:8126325-8127584 [Bradyrhizobium sp. LCT2]
ATGAACCATCTGCTGGATGTCTATTTCGGCAGCGTTAAGGCCGGCATCCTCAACCAGGATGATGCCGGGATGCTCAGCTA
CAGCTATGACACCGGCTACCTTGCCGGTGGGGCAGCTCGGGCAATCTCCTTTTCCATGCCGCTACAGGAGGCCCCCCACC
CGGATCGCATTGTCCGTCCCTTCTTTTCAGGCCTTTTGCCCGATGAGGGCGCCCGGCAACGTCTGGCTGGTGCGCTGGGG
ATCTCGGCAGGAAATGCCTTCGGTCTCCTTGAGGTGATTGGTGGGGAATGCGCAGGCGCCTTGTCACTCTATCCAGCCGG
TCAGGCACCTCCCTCCTCCGATGACGACGGTGTCGAAGTGCTCACTCCTGCCCGGCTCGAAGAAATTCTGGGCAAACTCC
GCGAGCGCCCCCTCCTCGGCGGAGAGGAGGGCGTGCGGCTGTCGCTCGCCGGAGTGCAGGACAAGCTCGCCGTTTGTCTT
GAGGGAGAGAGAATTGGACTCGCCAAGGGCGGGCGGCCGACCACGCACATTCTGAAGCCCTTCATTCAGGCGCTGGAGGG
AAGCGTCGAGAATGAACTCTTCTGTCTGCGCCTAGCTGCGCTCCTGACGCTGCCTGTGCCTGACGTCCAGATGCGACGGC
AGGGGGCCATTTCATATCTTCTAGTCGAGCGCTACGACCGTTCGAGAGACAACGATGGCACCATCTCGCGCCTGCATCAG
GAGGATTTCTGCCAGGCGTTGAGCGTTCCTCCAGAGCTCAAGTACGAGGAGGAAGGAGGACCTGGGACCGAGCGTTCACT
AGACCTCATCGGTCGCGCCACAGCACGCCCGGCAGCCGACCGGTTGAGCTTCATCCGCATGCTGATCTTTCACTATCTGG
TCGGCAATGCCGACGCGCATGGGAAGAACTATGCTCTGCTTTACCGAGGCGAGGTGCCGGACCTCGCCCCGCTCTATGAC
GTCGTCTGCACAGCAGCTTACCAGCGCTTGGCAAAGAAGCTCGCCATGGCCATTGGCGGGCGTTCGGTTCCGGATACGAT
CCAGTTGCAGCACTGGCTGACACTCGTTCCCGCAACACGCGGGGCACAGCGTTTGCTCATCAAGGATATCAAGGAATCGG
CAGACCGGATCAGAAGCGCGGCCGACGGCCTCCTGACGGAGCTGGAAGAGGCAGGCGTCACCCACGCGATTCTCAAGACG
ATCCGGACCGTCATTGAGACCCGCGCCTCTCATTTGCTTCGAATTACGGAGAAGGCGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8121.33 Da        Isoelectric Point: 10.7429

>AT116018 WP_161536358.1 NZ_CP034432:8126101-8126328 [Bradyrhizobium sp. LCT2]
MPKITTSKTLGNLIRDERKDQGLTQEQLAGLTGVGVRFVRELEAGKESCQLGRALQVAAALGLTVSVNSRRETPR

Download         Length: 228 bp

>AT116018 NZ_CP034432:8126101-8126328 [Bradyrhizobium sp. LCT2]
ATGCCGAAGATAACTACCAGCAAAACCCTCGGAAATCTGATCCGAGATGAACGCAAGGACCAAGGCCTAACGCAGGAACA
GCTTGCGGGCCTGACCGGGGTCGGCGTGCGTTTCGTGCGCGAATTGGAAGCCGGAAAAGAGAGCTGTCAGCTCGGTCGCG
CGCTTCAGGTCGCGGCCGCATTGGGTCTCACCGTTTCAGTCAACAGCCGTCGGGAGACGCCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References