Detailed information of TA system TA116005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 3577479..3577948
• Replicon: chromosome
• Accession: NZ_CP034425
• Organism: Pseudomonas libanensis strain DMSP-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EJJ21_RS16435
• Protein ID: WP_044273978.1
• Coordinates: 3577479..3577754 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1T1I1G5
• Locus tag: EJJ21_RS16440
• Protein ID: WP_044273976.1
• Coordinates: 3577754..3577948 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJJ21_RS16415	3572481..3573725	-	1245	WP_125970237.1	glutathione-dependent formaldehyde dehydrogenase	-
EJJ21_RS16420	3573810..3574928	-	1119	WP_125970944.1	carboxylate-amine ligase	-
EJJ21_RS16425	3574935..3575879	-	945	WP_125970238.1	class I SAM-dependent methyltransferase	-
EJJ21_RS16430	3575891..3577270	-	1380	WP_069558227.1	iron-containing redox enzyme family protein	-
EJJ21_RS16435	3577479..3577754	-	276	WP_044273978.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EJJ21_RS16440	3577754..3577948	-	195	WP_044273976.1	hypothetical protein	Antitoxin
EJJ21_RS16445	3578096..3579838	-	1743	WP_003192009.1	ABC transporter substrate-binding protein	-
EJJ21_RS16450	3580001..3580273	-	273	WP_014718862.1	DUF2160 domain-containing protein	-
EJJ21_RS16455	3580285..3581100	-	816	WP_124527973.1	carbohydrate ABC transporter permease	-
EJJ21_RS16460	3581111..3581977	-	867	WP_005789024.1	sugar ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10303.91 Da
• Isoelectric Point: 6.2166

>T116005 WP_044273978.1 NZ_CP034425:c3577754-3577479 [Pseudomonas libanensis]
MLSVVWLDEAISDLIDIVTFIAAENPGAARRIKTRLEGAPLPLTEHPYLYPNGRVPGTREVVVHPNYVLVYRVTAERIEI
VNVLHARQEYP

Nucleotide

• Length: 276 bp

>T116005 NZ_CP034425:c3577754-3577479 [Pseudomonas libanensis]
ATGTTGAGTGTCGTTTGGCTTGATGAGGCTATCAGCGACCTGATTGACATCGTTACTTTCATTGCAGCAGAGAATCCTGG
GGCTGCGCGTCGTATCAAGACACGTCTTGAAGGTGCGCCTCTGCCATTGACCGAGCATCCTTACCTGTATCCGAACGGCC
GCGTGCCCGGCACTCGGGAGGTCGTCGTTCACCCCAATTATGTCCTGGTGTATCGAGTAACAGCAGAGCGCATCGAGATA
GTCAACGTGTTGCACGCTCGGCAGGAGTATCCCTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7112.11 Da
• Isoelectric Point: 5.0509

>AT116005 WP_044273976.1 NZ_CP034425:c3577948-3577754 [Pseudomonas libanensis]
MGVPLSPIVSEFETEEQASSHDLWFRAKVEKSLANPGPGVPHDEVMARVEAIILEAERKQRVKA

Nucleotide

• Length: 195 bp

>AT116005 NZ_CP034425:c3577948-3577754 [Pseudomonas libanensis]
ATGGGTGTTCCACTTTCCCCAATTGTTTCCGAATTTGAAACTGAAGAGCAGGCAAGTAGCCATGATCTTTGGTTTCGCGC
CAAAGTAGAAAAAAGCCTGGCCAACCCCGGACCTGGTGTGCCCCATGACGAAGTCATGGCGAGGGTTGAGGCGATTATTC
TTGAAGCAGAACGCAAGCAGAGGGTCAAAGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1T1I1G5