Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4916645..4917161 Replicon chromosome
Accession NZ_CP034415
Organism Klebsiella pneumoniae strain C789

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag EJJ25_RS23955 Protein ID WP_002886902.1
Coordinates 4916645..4916929 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag EJJ25_RS23960 Protein ID WP_002886901.1
Coordinates 4916919..4917161 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJJ25_RS23935 4912129..4912437 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
EJJ25_RS29830 4912522..4912695 + 174 WP_002886906.1 hypothetical protein -
EJJ25_RS23940 4912698..4913441 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
EJJ25_RS23945 4913798..4915936 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
EJJ25_RS23950 4916177..4916641 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EJJ25_RS23955 4916645..4916929 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJJ25_RS23960 4916919..4917161 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EJJ25_RS23965 4917239..4919149 - 1911 WP_004152270.1 BglG family transcription antiterminator -
EJJ25_RS23970 4919172..4920326 - 1155 WP_002886900.1 lactonase family protein -
EJJ25_RS23975 4920392..4921132 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T115990 WP_002886902.1 NZ_CP034415:c4916929-4916645 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T115990 NZ_CP034415:c4916929-4916645 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT115990 WP_002886901.1 NZ_CP034415:c4917161-4916919 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT115990 NZ_CP034415:c4917161-4916919 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References