Detailed information of TA system TA115974

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1034948..1035513
• Replicon: chromosome
• Accession: NZ_CP034413
• Organism: Dysosmobacter welbionis strain J115

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7H6P5
• Locus tag: EIO64_RS05320
• Protein ID: WP_002596328.1
• Coordinates: 1035223..1035513 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C7H6P4
• Locus tag: EIO64_RS05315
• Protein ID: WP_005924829.1
• Coordinates: 1034948..1035226 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIO64_RS05280	1030805..1031131	-	327	WP_136890967.1	formate hydrogenlyase	-
EIO64_RS05285	1031131..1031940	-	810	Protein_1033	type IV secretory system conjugative DNA transfer family protein	-
EIO64_RS05290	1032034..1032399	-	366	WP_014080225.1	hypothetical protein	-
EIO64_RS05295	1032477..1032671	-	195	WP_005933543.1	transposon-encoded TnpW family protein	-
EIO64_RS05300	1032715..1033578	-	864	WP_005933545.1	ATP-binding protein	-
EIO64_RS05305	1033575..1034309	-	735	WP_112091012.1	phage replisome organizer N-terminal domain-containing protein	-
EIO64_RS05310	1034423..1034821	-	399	WP_055153539.1	cysteine-rich VLP domain-containing protein	-
EIO64_RS05315	1034948..1035226	+	279	WP_005924829.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EIO64_RS05320	1035223..1035513	+	291	WP_002596328.1	type II toxin-antitoxin system YafQ family toxin	Toxin
EIO64_RS05325	1035621..1037066	-	1446	WP_112091013.1	MobA/MobL family protein	-
EIO64_RS05330	1037353..1038378	-	1026	WP_136890968.1	tyrosine-type recombinase/integrase	-
EIO64_RS05335	1038365..1039354	-	990	WP_136890969.1	tyrosine-type recombinase/integrase	-
EIO64_RS05340	1039351..1040322	-	972	WP_136890970.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(W)	-	946722..1074452	127730

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-90)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11112.87 Da
• Isoelectric Point: 8.0630

>T115974 WP_002596328.1 NZ_CP034413:1035223-1035513 [Dysosmobacter welbionis]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Nucleotide

• Length: 291 bp

>T115974 NZ_CP034413:1035223-1035513 [Dysosmobacter welbionis]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATCGAGCTGCTGGAGCAGGTCGTAGCGTTGCTGGCGATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10247.66 Da
• Isoelectric Point: 4.4692

>AT115974 WP_005924829.1 NZ_CP034413:1034948-1035226 [Dysosmobacter welbionis]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Nucleotide

• Length: 279 bp

>AT115974 NZ_CP034413:1034948-1035226 [Dysosmobacter welbionis]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA

Structures

Toxin

• AlphaFold DB: A0A1M4XBM1

Antitoxin

• AlphaFold DB: A0A1M4XB19