Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 2789747..2790258 Replicon chromosome
Accession NZ_CP034412
Organism Glutamicibacter creatinolyticus strain LGCM 259

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag GcLGCM259_RS12840 Protein ID WP_138926845.1
Coordinates 2789747..2790013 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GcLGCM259_RS12845 Protein ID WP_138926846.1
Coordinates 2790010..2790258 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GcLGCM259_RS12815 2784849..2785553 + 705 WP_138926842.1 CoA transferase subunit A -
GcLGCM259_RS12820 2785556..2786206 + 651 WP_138927258.1 CoA transferase subunit B -
GcLGCM259_RS12825 2786203..2787372 + 1170 WP_138926843.1 acetyl-CoA C-acyltransferase -
GcLGCM259_RS12830 2787533..2788726 + 1194 WP_138926844.1 NAD(P)/FAD-dependent oxidoreductase -
GcLGCM259_RS12835 2788817..2789380 - 564 WP_138175717.1 histidine phosphatase family protein -
GcLGCM259_RS12840 2789747..2790013 - 267 WP_138926845.1 Txe/YoeB family addiction module toxin Toxin
GcLGCM259_RS12845 2790010..2790258 - 249 WP_138926846.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GcLGCM259_RS12850 2790477..2791424 + 948 WP_138926847.1 ketoacyl-ACP synthase III -
GcLGCM259_RS12855 2791489..2791887 + 399 WP_138926848.1 VOC family protein -
GcLGCM259_RS12860 2792001..2792717 + 717 WP_138926849.1 FadR family transcriptional regulator -
GcLGCM259_RS12865 2792774..2793808 + 1035 WP_138926850.1 asparaginase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2771724..2790258 18534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10100.43 Da        Isoelectric Point: 5.6907

>T115973 WP_138926845.1 NZ_CP034412:c2790013-2789747 [Glutamicibacter creatinolyticus]
MSDRVLAWTEAGWEDCLYWQTQDRKTLKRINALIEDILGDEPPEGIGKSEALKHALAGAWSRRIDAVNRLAYIADDRAVT
ILQARYHY

Download         Length: 267 bp

>T115973 NZ_CP034412:c2790013-2789747 [Glutamicibacter creatinolyticus]
ATGAGCGACAGAGTGCTCGCATGGACTGAAGCGGGATGGGAAGACTGTCTCTACTGGCAAACCCAAGACAGAAAAACGCT
CAAGCGCATCAACGCGCTGATCGAAGACATCCTGGGCGATGAGCCCCCTGAAGGGATCGGCAAATCCGAAGCCCTAAAAC
ACGCCTTGGCTGGCGCATGGTCGCGGCGCATCGATGCAGTCAATCGGCTCGCCTATATTGCTGATGACCGCGCAGTGACG
ATCTTGCAGGCGCGGTATCACTACTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8979.13 Da        Isoelectric Point: 4.7954

>AT115973 WP_138926846.1 NZ_CP034412:c2790258-2790010 [Glutamicibacter creatinolyticus]
VAITASEARRALFGSVEKVNLDQTEVEIVSKRGSAILMSKDEYDALVETSYLLRSPKNALRLLEAFKSAQEGNSTEHGLI
DP

Download         Length: 249 bp

>AT115973 NZ_CP034412:c2790258-2790010 [Glutamicibacter creatinolyticus]
GTGGCGATAACAGCGAGTGAAGCGCGTCGTGCTTTGTTTGGGTCGGTTGAGAAGGTCAATCTTGACCAAACGGAAGTTGA
GATTGTGTCCAAGCGGGGCTCGGCGATCCTGATGTCGAAAGACGAATACGACGCCTTGGTCGAGACAAGCTACTTGCTGA
GGTCTCCCAAGAACGCACTGCGCCTGCTTGAAGCGTTTAAATCAGCGCAGGAAGGAAATTCAACTGAGCATGGGCTCATT
GACCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References