Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 2244181..2244696 Replicon chromosome
Accession NZ_CP034412
Organism Glutamicibacter creatinolyticus strain LGCM 259

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GcLGCM259_RS10260 Protein ID WP_138926559.1
Coordinates 2244181..2244435 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GcLGCM259_RS10265 Protein ID WP_138926560.1
Coordinates 2244436..2244696 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GcLGCM259_RS10235 2239813..2240727 - 915 WP_175419392.1 endonuclease/exonuclease/phosphatase family protein -
GcLGCM259_RS10240 2240959..2241666 + 708 WP_138926555.1 MSMEG_4193 family putative phosphomutase -
GcLGCM259_RS10245 2241676..2242197 + 522 WP_138926556.1 DUF3090 domain-containing protein -
GcLGCM259_RS10250 2242197..2242964 + 768 WP_138926557.1 SCO1664 family protein -
GcLGCM259_RS10255 2243182..2243622 - 441 WP_138926558.1 YtoQ family protein -
GcLGCM259_RS10260 2244181..2244435 - 255 WP_138926559.1 Txe/YoeB family addiction module toxin Toxin
GcLGCM259_RS10265 2244436..2244696 - 261 WP_138926560.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GcLGCM259_RS10270 2245051..2245506 - 456 Protein_1989 transposase -
GcLGCM259_RS10275 2245530..2246632 - 1103 Protein_1990 IS256 family transposase -
GcLGCM259_RS10280 2247117..2247464 - 348 WP_138926561.1 antirestriction protein ArdA -
GcLGCM259_RS10285 2247591..2249147 - 1557 WP_138926562.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2221783..2259154 37371
- flank IS/Tn - - 2245051..2245395 344


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10165.53 Da        Isoelectric Point: 6.7173

>T115972 WP_138926559.1 NZ_CP034412:c2244435-2244181 [Glutamicibacter creatinolyticus]
VRLVWDESAWEDYKHWQTADRKILKRINTLIDACLREPFYGIGKPEQLKYGAQGSWSRRITDEHRLVYLVEDEDLVILQA
RYHY

Download         Length: 255 bp

>T115972 NZ_CP034412:c2244435-2244181 [Glutamicibacter creatinolyticus]
GTGCGTCTAGTCTGGGACGAGTCAGCTTGGGAGGACTACAAGCACTGGCAGACGGCCGACCGGAAGATCCTGAAGCGCAT
CAACACTCTCATCGATGCCTGTTTGCGCGAACCGTTCTACGGGATCGGCAAGCCCGAGCAGCTAAAGTATGGAGCGCAGG
GCTCGTGGTCACGGCGCATCACCGATGAGCACCGGCTCGTCTACCTGGTGGAGGATGAGGACCTCGTGATTCTTCAGGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9808.90 Da        Isoelectric Point: 4.9108

>AT115972 WP_138926560.1 NZ_CP034412:c2244696-2244436 [Glutamicibacter creatinolyticus]
MSISASEARKTLFPLIERVNEDRDAVEIVSRKGNAVLMSAEEYAAWQETAYLFRSPANARRLLDAYERARAGKHEVHDLD
RADEET

Download         Length: 261 bp

>AT115972 NZ_CP034412:c2244696-2244436 [Glutamicibacter creatinolyticus]
ATGTCCATCAGCGCAAGCGAGGCGCGCAAGACCTTGTTCCCTCTCATTGAGCGCGTGAATGAGGACCGTGATGCCGTTGA
GATCGTTTCTCGTAAGGGCAACGCTGTTCTGATGTCGGCCGAGGAATATGCTGCGTGGCAGGAAACCGCCTACCTGTTCC
GCTCGCCGGCCAACGCCCGCCGGCTGCTCGATGCCTACGAACGTGCCCGCGCCGGAAAGCACGAGGTTCACGACCTGGAT
CGCGCCGACGAGGAAACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References