Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 5146753..5147321 Replicon chromosome
Accession NZ_CP034409
Organism Pseudomonas aeruginosa strain SP4527

Toxin (Protein)


Gene name parE Uniprot ID A0A0D0R3P1
Locus tag EJA97_RS24235 Protein ID WP_011222050.1
Coordinates 5146753..5147046 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6M3UV67
Locus tag EJA97_RS24240 Protein ID WP_011222051.1
Coordinates 5147034..5147321 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJA97_RS24200 5142001..5142900 + 900 WP_032494864.1 class A extended-spectrum beta-lactamase VEB-9 -
EJA97_RS24205 5143634..5144824 - 1191 WP_033991588.1 tetracycline efflux MFS transporter Tet(A) -
EJA97_RS24210 5144930..5145580 + 651 WP_000164043.1 tetracycline resistance transcriptional repressor TetR(A) -
EJA97_RS24215 5145612..5145854 - 243 WP_000844627.1 transposase -
EJA97_RS24225 5146283..5146468 + 186 Protein_4651 multidrug transporter -
EJA97_RS33330 5146504..5146815 + 312 WP_052150402.1 hypothetical protein -
EJA97_RS24235 5146753..5147046 - 294 WP_011222050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJA97_RS24240 5147034..5147321 - 288 WP_011222051.1 CopG family ribbon-helix-helix protein Antitoxin
EJA97_RS24245 5147494..5147700 - 207 WP_033991586.1 hypothetical protein -
EJA97_RS24250 5147935..5149614 + 1680 WP_000179844.1 DDE-type integrase/transposase/recombinase -
EJA97_RS24255 5149617..5150609 + 993 WP_001381192.1 TniB family NTP-binding protein -
EJA97_RS24260 5150578..5151078 - 501 WP_000376623.1 GNAT family N-acetyltransferase -
EJA97_RS24270 5151206..5152045 - 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10890.71 Da        Isoelectric Point: 10.8518

>T115971 WP_011222050.1 NZ_CP034409:c5147046-5146753 [Pseudomonas aeruginosa]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Download         Length: 294 bp

>T115971 NZ_CP034409:c5147046-5146753 [Pseudomonas aeruginosa]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCAGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTCATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10922.19 Da        Isoelectric Point: 5.1897

>AT115971 WP_011222051.1 NZ_CP034409:c5147321-5147034 [Pseudomonas aeruginosa]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEETDQWLA
GWGTEIEGGAPACHK

Download         Length: 288 bp

>AT115971 NZ_CP034409:c5147321-5147034 [Pseudomonas aeruginosa]
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGACCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D0R3P1

Antitoxin

Source ID Structure
AlphaFold DB A0A6M3UV67

References