Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
Location | 5146753..5147321 | Replicon | chromosome |
Accession | NZ_CP034409 | ||
Organism | Pseudomonas aeruginosa strain SP4527 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A0D0R3P1 |
Locus tag | EJA97_RS24235 | Protein ID | WP_011222050.1 |
Coordinates | 5146753..5147046 (-) | Length | 98 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A6M3UV67 |
Locus tag | EJA97_RS24240 | Protein ID | WP_011222051.1 |
Coordinates | 5147034..5147321 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EJA97_RS24200 | 5142001..5142900 | + | 900 | WP_032494864.1 | class A extended-spectrum beta-lactamase VEB-9 | - |
EJA97_RS24205 | 5143634..5144824 | - | 1191 | WP_033991588.1 | tetracycline efflux MFS transporter Tet(A) | - |
EJA97_RS24210 | 5144930..5145580 | + | 651 | WP_000164043.1 | tetracycline resistance transcriptional repressor TetR(A) | - |
EJA97_RS24215 | 5145612..5145854 | - | 243 | WP_000844627.1 | transposase | - |
EJA97_RS24225 | 5146283..5146468 | + | 186 | Protein_4651 | multidrug transporter | - |
EJA97_RS33330 | 5146504..5146815 | + | 312 | WP_052150402.1 | hypothetical protein | - |
EJA97_RS24235 | 5146753..5147046 | - | 294 | WP_011222050.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EJA97_RS24240 | 5147034..5147321 | - | 288 | WP_011222051.1 | CopG family ribbon-helix-helix protein | Antitoxin |
EJA97_RS24245 | 5147494..5147700 | - | 207 | WP_033991586.1 | hypothetical protein | - |
EJA97_RS24250 | 5147935..5149614 | + | 1680 | WP_000179844.1 | DDE-type integrase/transposase/recombinase | - |
EJA97_RS24255 | 5149617..5150609 | + | 993 | WP_001381192.1 | TniB family NTP-binding protein | - |
EJA97_RS24260 | 5150578..5151078 | - | 501 | WP_000376623.1 | GNAT family N-acetyltransferase | - |
EJA97_RS24270 | 5151206..5152045 | - | 840 | WP_000259031.1 | sulfonamide-resistant dihydropteroate synthase Sul1 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 10890.71 Da Isoelectric Point: 10.8518
>T115971 WP_011222050.1 NZ_CP034409:c5147046-5146753 [Pseudomonas aeruginosa]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI
Download Length: 294 bp
>T115971 NZ_CP034409:c5147046-5146753 [Pseudomonas aeruginosa]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCAGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTCATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCAGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTCATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10922.19 Da Isoelectric Point: 5.1897
>AT115971 WP_011222051.1 NZ_CP034409:c5147321-5147034 [Pseudomonas aeruginosa]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEETDQWLA
GWGTEIEGGAPACHK
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEETDQWLA
GWGTEIEGGAPACHK
Download Length: 288 bp
>AT115971 NZ_CP034409:c5147321-5147034 [Pseudomonas aeruginosa]
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGACCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGACCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D0R3P1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6M3UV67 |