Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5045830..5046335 Replicon chromosome
Accession NZ_CP034409
Organism Pseudomonas aeruginosa strain SP4527

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag EJA97_RS23700 Protein ID WP_031640969.1
Coordinates 5046054..5046335 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EJA97_RS23695 Protein ID WP_003083775.1
Coordinates 5045830..5046057 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJA97_RS23670 5040849..5042342 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
EJA97_RS23675 5042511..5043938 + 1428 WP_003083784.1 GABA permease -
EJA97_RS23680 5044020..5044361 - 342 WP_003101229.1 alkylphosphonate utilization protein -
EJA97_RS23685 5044433..5044933 - 501 WP_003101228.1 LEA type 2 family protein -
EJA97_RS23690 5045034..5045654 + 621 WP_003101226.1 hypothetical protein -
EJA97_RS23695 5045830..5046057 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EJA97_RS23700 5046054..5046335 + 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
EJA97_RS23705 5046635..5047543 + 909 WP_033990895.1 LysR family transcriptional regulator -
EJA97_RS23710 5047575..5047961 - 387 WP_003083767.1 aegerolysin family protein -
EJA97_RS23715 5048165..5048899 - 735 WP_003128333.1 GntR family transcriptional regulator -
EJA97_RS23720 5049000..5049686 - 687 WP_003083762.1 FadR family transcriptional regulator -
EJA97_RS23725 5049735..5051084 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T115970 WP_031640969.1 NZ_CP034409:5046054-5046335 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T115970 NZ_CP034409:5046054-5046335 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGAACCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT115970 WP_003083775.1 NZ_CP034409:5045830-5046057 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT115970 NZ_CP034409:5045830-5046057 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References