Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3832715..3833301 Replicon chromosome
Accession NZ_CP034409
Organism Pseudomonas aeruginosa strain SP4527

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag EJA97_RS18115 Protein ID WP_003120987.1
Coordinates 3833002..3833301 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag EJA97_RS18110 Protein ID WP_003448662.1
Coordinates 3832715..3833005 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJA97_RS18095 3828296..3830185 + 1890 WP_033989533.1 hypothetical protein -
EJA97_RS18100 3830182..3832158 + 1977 WP_022579622.1 DEAD/DEAH box helicase -
EJA97_RS18105 3832297..3832632 + 336 WP_022579623.1 hypothetical protein -
EJA97_RS18110 3832715..3833005 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
EJA97_RS18115 3833002..3833301 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJA97_RS18120 3833503..3834627 + 1125 WP_023093672.1 TcpQ domain-containing protein -
EJA97_RS18125 3834627..3836336 + 1710 WP_023093673.1 PilN family type IVB pilus formation outer membrane protein -
EJA97_RS18130 3836340..3837665 + 1326 WP_022579625.1 type 4b pilus protein PilO2 -
EJA97_RS18135 3837655..3838188 + 534 WP_004352829.1 type IV pilus biogenesis protein PilP -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3802866..3893221 90355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T115968 WP_003120987.1 NZ_CP034409:c3833301-3833002 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

>T115968 NZ_CP034409:c3833301-3833002 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT115968 WP_003448662.1 NZ_CP034409:c3833005-3832715 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp

>AT115968 NZ_CP034409:c3833005-3832715 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCTCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTTTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G8CP73


Antitoxin

Source ID Structure

References