115967

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 3435559..3436167 Replicon chromosome
Accession NZ_CP034409
Organism Pseudomonas aeruginosa strain SP4527

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag EJA97_RS16230 Protein ID WP_019486378.1
Coordinates 3435559..3435906 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag EJA97_RS16235 Protein ID WP_003114155.1
Coordinates 3435916..3436167 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJA97_RS16200 3430918..3431190 + 273 WP_074241374.1 cysteine-rich CWC family protein -
EJA97_RS16205 3431190..3431882 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
EJA97_RS16210 3432018..3433061 + 1044 WP_003134392.1 L,D-transpeptidase -
EJA97_RS16215 3433141..3433878 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
EJA97_RS16220 3434330..3435232 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
EJA97_RS16230 3435559..3435906 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJA97_RS16235 3435916..3436167 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EJA97_RS16240 3436381..3437364 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
EJA97_RS16245 3437364..3438656 - 1293 WP_003123045.1 hypothetical protein -
EJA97_RS16250 3438886..3440169 - 1284 WP_127005388.1 zonular occludens toxin family protein -
EJA97_RS16255 3440173..3440529 - 357 WP_003114150.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T115967 WP_019486378.1 NZ_CP034409:c3435906-3435559 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T115967 NZ_CP034409:c3435906-3435559 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGTGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT115967 WP_003114155.1 NZ_CP034409:c3436167-3435916 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT115967 NZ_CP034409:c3436167-3435916 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGACTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References