Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 45179..45701 | Replicon | plasmid pCRE10.3 |
| Accession | NZ_CP034405 | ||
| Organism | Escherichia coli strain CRE10 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | EJC75_RS25960 | Protein ID | WP_000638823.1 |
| Coordinates | 45179..45460 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | EJC75_RS25965 | Protein ID | WP_000121741.1 |
| Coordinates | 45450..45701 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EJC75_RS25925 | 41333..41653 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| EJC75_RS25930 | 41724..41912 | - | 189 | WP_050567133.1 | hypothetical protein | - |
| EJC75_RS25935 | 42014..42598 | - | 585 | WP_129484133.1 | lytic transglycosylase domain-containing protein | - |
| EJC75_RS25940 | 42619..43017 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| EJC75_RS25945 | 43136..43573 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| EJC75_RS25950 | 43579..44809 | - | 1231 | Protein_44 | TcpQ domain-containing protein | - |
| EJC75_RS25955 | 44812..45111 | - | 300 | WP_000835764.1 | IncN plasmid KikA protein | - |
| EJC75_RS25960 | 45179..45460 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EJC75_RS25965 | 45450..45701 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| EJC75_RS25970 | 45801..46436 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| EJC75_RS25975 | 46509..46796 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| EJC75_RS25980 | 46809..47063 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| EJC75_RS25985 | 47065..47706 | - | 642 | WP_001425343.1 | conjugal transfer protein TrbJ | - |
| EJC75_RS25990 | 47712..48707 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| EJC75_RS25995 | 48711..48968 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| EJC75_RS26000 | 48965..49267 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| EJC75_RS26005 | 49248..49505 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| EJC75_RS26010 | 49538..49984 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| EJC75_RS26345 | 49995..50165 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| EJC75_RS26015 | 50169..50612 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | mcr-1.1 | - | 1..61684 | 61684 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T115943 WP_000638823.1 NZ_CP034405:c45460-45179 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T115943 NZ_CP034405:c45460-45179 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT115943 WP_000121741.1 NZ_CP034405:c45701-45450 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT115943 NZ_CP034405:c45701-45450 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|