Detailed information of TA system TA115939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4003165..4003985
• Replicon: chromosome
• Accession: NZ_CP034404
• Organism: Escherichia coli strain CRE10

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: EJC75_RS21365
• Protein ID: WP_001054379.1
• Coordinates: 4003728..4003985 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: EJC75_RS21360
• Protein ID: WP_000123957.1
• Coordinates: 4003165..4003716 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJC75_RS21335	3998859..4000172	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
EJC75_RS21340	4000184..4000462	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
EJC75_RS21345	4000459..4001580	-	1122	WP_000010833.1	M42 family metallopeptidase	-
EJC75_RS26450	4001825..4001941	-	117	Protein_3722	VOC family protein	-
EJC75_RS21350	4001979..4002239	-	261	WP_000077646.1	hypothetical protein	-
EJC75_RS21355	4002367..4003113	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
EJC75_RS21360	4003165..4003716	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
EJC75_RS21365	4003728..4003985	-	258	WP_001054379.1	YjhX family toxin	Toxin
EJC75_RS21370	4004362..4004661	-	300	WP_001332034.1	GNAT family N-acetyltransferase	-
EJC75_RS21375	4004739..4005965	+	1227	Protein_3728	DNA helicase	-
EJC75_RS21380	4006548..4007528	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
EJC75_RS21385	4007592..4008698	-	1107	WP_001295733.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T115939 WP_001054379.1 NZ_CP034404:c4003985-4003728 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T115939 NZ_CP034404:c4003985-4003728 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT115939 WP_000123957.1 NZ_CP034404:c4003716-4003165 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT115939 NZ_CP034404:c4003716-4003165 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030