Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4256139..4256983 Replicon chromosome
Accession NZ_CP034399
Organism Escherichia coli strain CRE1

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag EJC48_RS22340 Protein ID WP_000854686.1
Coordinates 4256600..4256983 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag EJC48_RS22335 Protein ID WP_001285602.1
Coordinates 4256139..4256519 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJC48_RS22295 4252387..4252842 + 456 WP_000581506.1 hypothetical protein -
EJC48_RS22300 4252943..4253151 + 209 Protein_3904 DUF905 family protein -
EJC48_RS22310 4253252..4254073 + 822 WP_001761104.1 DUF945 domain-containing protein -
EJC48_RS22315 4254165..4254650 + 486 WP_000214307.1 antirestriction protein -
EJC48_RS22320 4254666..4255142 + 477 WP_129484016.1 RadC family protein -
EJC48_RS22325 4255205..4255426 + 222 WP_000692298.1 DUF987 domain-containing protein -
EJC48_RS22330 4255445..4256128 + 684 WP_000086768.1 hypothetical protein -
EJC48_RS22335 4256139..4256519 + 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EJC48_RS22340 4256600..4256983 + 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
EJC48_RS22345 4256980..4257468 + 489 WP_032180032.1 hypothetical protein -
EJC48_RS22350 4257485..4257682 + 198 WP_000839253.1 DUF957 domain-containing protein -
EJC48_RS22355 4257767..4258608 + 842 Protein_3914 DUF4942 domain-containing protein -
EJC48_RS22365 4259079..4260017 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
EJC48_RS22370 4260072..4260809 + 738 WP_000283664.1 zinc-binding phosphatase -
EJC48_RS22375 4260833..4261387 + 555 WP_001001902.1 molecular chaperone YcdY -
EJC48_RS22380 4261489..4261980 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCMY-2 csgG / csgF / csgE / csgD / csgB / csgA / csgC 4209958..4266916 56958


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T115903 WP_000854686.1 NZ_CP034399:4256600-4256983 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T115903 NZ_CP034399:4256600-4256983 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT115903 WP_001285602.1 NZ_CP034399:4256139-4256519 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT115903 NZ_CP034399:4256139-4256519 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References