115898

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2880993..2881813 Replicon chromosome
Accession NZ_CP034399
Organism Escherichia coli strain CRE1

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag EJC48_RS15825 Protein ID WP_001054379.1
Coordinates 2881556..2881813 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag EJC48_RS15820 Protein ID WP_000123957.1
Coordinates 2880993..2881544 (-) Length 184 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJC48_RS15795 2876687..2878000 - 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -
EJC48_RS15800 2878012..2878290 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EJC48_RS15805 2878287..2879408 - 1122 WP_000010833.1 M42 family metallopeptidase -
EJC48_RS26470 2879653..2879769 - 117 Protein_2659 VOC family protein -
EJC48_RS15810 2879807..2880067 - 261 WP_000077646.1 hypothetical protein -
EJC48_RS15815 2880195..2880941 - 747 WP_000354249.1 class I SAM-dependent methyltransferase -
EJC48_RS15820 2880993..2881544 - 552 WP_000123957.1 N-acetyltransferase Antitoxin
EJC48_RS15825 2881556..2881813 - 258 WP_001054379.1 YjhX family toxin Toxin
EJC48_RS15830 2882190..2882489 - 300 WP_001332034.1 GNAT family N-acetyltransferase -
EJC48_RS15835 2882567..2883793 + 1227 Protein_2665 DNA helicase -
EJC48_RS15840 2884376..2885356 - 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EJC48_RS15845 2885423..2886528 - 1106 Protein_2667 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(19-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T115898 WP_001054379.1 NZ_CP034399:c2881813-2881556 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T115898 NZ_CP034399:c2881813-2881556 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT115898 WP_000123957.1 NZ_CP034399:c2881544-2880993 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp

>AT115898 NZ_CP034399:c2881544-2880993 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB B6I030


Antitoxin

Source ID Structure

References