Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4284555..4285387 Replicon chromosome
Accession NZ_CP034389
Organism Escherichia coli strain RS571

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0Q2Y5N3
Locus tag EJH97_RS20970 Protein ID WP_001514886.1
Coordinates 4284555..4284929 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag EJH97_RS20975 Protein ID WP_001295723.1
Coordinates 4285019..4285387 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJH97_RS26535 4282280..4282438 - 159 WP_001467148.1 hypothetical protein -
EJH97_RS20950 4282538..4282714 - 177 WP_000839290.1 DUF957 domain-containing protein -
EJH97_RS20955 4282731..4283093 - 363 Protein_4042 hypothetical protein -
EJH97_RS20960 4283187..4284415 + 1229 WP_164930399.1 IS3 family transposase -
EJH97_RS20965 4284340..4284558 - 219 WP_001514887.1 hypothetical protein -
EJH97_RS20970 4284555..4284929 - 375 WP_001514886.1 TA system toxin CbtA family protein Toxin
EJH97_RS20975 4285019..4285387 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EJH97_RS20980 4285550..4285771 - 222 WP_000692286.1 DUF987 domain-containing protein -
EJH97_RS20985 4285834..4286310 - 477 WP_001186774.1 RadC family protein -
EJH97_RS20990 4286326..4286799 - 474 WP_000855059.1 antirestriction protein -
EJH97_RS21000 4287141..4287959 - 819 WP_001234729.1 DUF945 domain-containing protein -
EJH97_RS21010 4288114..4288272 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13930.91 Da        Isoelectric Point: 7.2909

>T115855 WP_001514886.1 NZ_CP034389:c4284929-4284555 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T115855 NZ_CP034389:c4284929-4284555 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT115855 WP_001295723.1 NZ_CP034389:c4285387-4285019 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT115855 NZ_CP034389:c4285387-4285019 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q2Y5N3

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References