Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1263162..1263640 Replicon chromosome
Accession NZ_CP034384
Organism Escherichia coli O157:H7 strain FRIK804

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag EJB16_RS05845 Protein ID WP_001303876.1
Coordinates 1263162..1263449 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag EJB16_RS05850 Protein ID WP_000536233.1
Coordinates 1263449..1263640 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJB16_RS05815 1258311..1260782 - 2472 WP_000034474.1 exonuclease -
EJB16_RS05820 1260876..1261067 - 192 WP_001098307.1 DUF1482 family protein -
EJB16_RS05825 1261064..1261252 - 189 WP_000413705.1 cell division inhibition protein DicB -
EJB16_RS05830 1261826..1262011 + 186 WP_001133046.1 hypothetical protein -
EJB16_RS05835 1262198..1262587 - 390 WP_000394511.1 hypothetical protein -
EJB16_RS05840 1262729..1262884 - 156 WP_000379575.1 DUF1391 family protein -
EJB16_RS05845 1263162..1263449 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJB16_RS05850 1263449..1263640 - 192 WP_000536233.1 hypothetical protein Antitoxin
EJB16_RS05855 1263668..1264069 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
EJB16_RS05860 1264178..1264450 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
EJB16_RS05865 1264434..1264859 + 426 WP_000693855.1 Rha family transcriptional regulator -
EJB16_RS05870 1265066..1265521 - 456 WP_000273724.1 hypothetical protein -
EJB16_RS05875 1265600..1266691 + 1092 WP_001205823.1 hypothetical protein -
EJB16_RS05880 1266698..1267444 + 747 WP_000788751.1 ATP-binding protein -
EJB16_RS05885 1267466..1268236 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T115808 WP_001303876.1 NZ_CP034384:c1263449-1263162 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T115808 NZ_CP034384:c1263449-1263162 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT115808 WP_000536233.1 NZ_CP034384:c1263640-1263449 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT115808 NZ_CP034384:c1263640-1263449 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References