Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 1263162..1263640 | Replicon | chromosome |
Accession | NZ_CP034384 | ||
Organism | Escherichia coli O157:H7 strain FRIK804 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A891SFN9 |
Locus tag | EJB16_RS05845 | Protein ID | WP_001303876.1 |
Coordinates | 1263162..1263449 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XD67 |
Locus tag | EJB16_RS05850 | Protein ID | WP_000536233.1 |
Coordinates | 1263449..1263640 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EJB16_RS05815 | 1258311..1260782 | - | 2472 | WP_000034474.1 | exonuclease | - |
EJB16_RS05820 | 1260876..1261067 | - | 192 | WP_001098307.1 | DUF1482 family protein | - |
EJB16_RS05825 | 1261064..1261252 | - | 189 | WP_000413705.1 | cell division inhibition protein DicB | - |
EJB16_RS05830 | 1261826..1262011 | + | 186 | WP_001133046.1 | hypothetical protein | - |
EJB16_RS05835 | 1262198..1262587 | - | 390 | WP_000394511.1 | hypothetical protein | - |
EJB16_RS05840 | 1262729..1262884 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
EJB16_RS05845 | 1263162..1263449 | - | 288 | WP_001303876.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EJB16_RS05850 | 1263449..1263640 | - | 192 | WP_000536233.1 | hypothetical protein | Antitoxin |
EJB16_RS05855 | 1263668..1264069 | - | 402 | WP_000986592.1 | helix-turn-helix domain-containing protein | - |
EJB16_RS05860 | 1264178..1264450 | + | 273 | WP_000887453.1 | helix-turn-helix domain-containing protein | - |
EJB16_RS05865 | 1264434..1264859 | + | 426 | WP_000693855.1 | Rha family transcriptional regulator | - |
EJB16_RS05870 | 1265066..1265521 | - | 456 | WP_000273724.1 | hypothetical protein | - |
EJB16_RS05875 | 1265600..1266691 | + | 1092 | WP_001205823.1 | hypothetical protein | - |
EJB16_RS05880 | 1266698..1267444 | + | 747 | WP_000788751.1 | ATP-binding protein | - |
EJB16_RS05885 | 1267466..1268236 | + | 771 | WP_000450992.1 | DUF1627 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10978.84 Da Isoelectric Point: 10.1360
>T115808 WP_001303876.1 NZ_CP034384:c1263449-1263162 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
Download Length: 288 bp
>T115808 NZ_CP034384:c1263449-1263162 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7025.80 Da Isoelectric Point: 4.0270
>AT115808 WP_000536233.1 NZ_CP034384:c1263640-1263449 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
Download Length: 192 bp
>AT115808 NZ_CP034384:c1263640-1263449 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|
Antitoxin
Source | ID | Structure |
---|