Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1150099..1150897 Replicon chromosome
Accession NZ_CP034384
Organism Escherichia coli O157:H7 strain FRIK804

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0V7WHV8
Locus tag EJB16_RS05350 Protein ID WP_001506713.1
Coordinates 1150520..1150897 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A093DMQ4
Locus tag EJB16_RS05345 Protein ID WP_001280952.1
Coordinates 1150099..1150473 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJB16_RS05315 1145447..1146352 + 906 WP_021497799.1 yjcZ-like family protein -
EJB16_RS05320 1146349..1147419 + 1071 WP_000102643.1 patatin-like phospholipase family protein -
EJB16_RS05325 1147759..1148577 + 819 WP_001506712.1 DUF945 domain-containing protein -
EJB16_RS05330 1148669..1149154 + 486 WP_001470565.1 antirestriction protein -
EJB16_RS05335 1149170..1149646 + 477 WP_001186714.1 RadC family protein -
EJB16_RS05340 1149715..1149936 + 222 WP_001220316.1 DUF987 domain-containing protein -
EJB16_RS05345 1150099..1150473 + 375 WP_001280952.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EJB16_RS05350 1150520..1150897 + 378 WP_001506713.1 TA system toxin CbtA family protein Toxin
EJB16_RS05355 1150894..1151382 + 489 WP_001470575.1 hypothetical protein -
EJB16_RS05360 1151394..1151591 + 198 WP_000839282.1 DUF957 domain-containing protein -
EJB16_RS05365 1151676..1152518 + 843 WP_001688445.1 DUF4942 domain-containing protein -
EJB16_RS05375 1153009..1153227 - 219 WP_001040187.1 translation initiation factor IF-1 -
EJB16_RS05380 1153512..1154216 - 705 WP_001241680.1 leucyl/phenylalanyl-tRNA--protein transferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-118)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14178.26 Da        Isoelectric Point: 7.8045

>T115807 WP_001506713.1 NZ_CP034384:1150520-1150897 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYITVNNITLGKHPEAKR

Download         Length: 378 bp

>T115807 NZ_CP034384:1150520-1150897 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACATAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13719.50 Da        Isoelectric Point: 6.6249

>AT115807 WP_001280952.1 NZ_CP034384:1150099-1150473 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT115807 NZ_CP034384:1150099-1150473 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0V7WHV8


Antitoxin

Source ID Structure
AlphaFold DB A0A093DMQ4

References