Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1039661..1040366 Replicon chromosome
Accession NZ_CP034384
Organism Escherichia coli O157:H7 strain FRIK804

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag EJB16_RS04910 Protein ID WP_000539519.1
Coordinates 1039980..1040366 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EJB16_RS04905 Protein ID WP_001280945.1
Coordinates 1039661..1039990 (-) Length 110 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJB16_RS04890 1034818..1035729 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
EJB16_RS04895 1035907..1038255 + 2349 WP_000950320.1 EAL domain-containing protein -
EJB16_RS04900 1038263..1039591 + 1329 WP_000086905.1 GGDEF domain-containing protein -
EJB16_RS04905 1039661..1039990 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
EJB16_RS04910 1039980..1040366 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJB16_RS04915 1040592..1041917 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
EJB16_RS04920 1042130..1042513 + 384 WP_000497137.1 biofilm formation regulator BssR -
EJB16_RS04925 1042624..1043739 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
EJB16_RS04930 1043736..1044362 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-124)

Antitoxin

(53-94)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T115805 WP_000539519.1 NZ_CP034384:c1040366-1039980 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T115805 NZ_CP034384:c1040366-1039980 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT115805 WP_001280945.1 NZ_CP034384:c1039990-1039661 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT115805 NZ_CP034384:c1039990-1039661 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References