Detailed information of TA system TA115800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 6040779..6041347
• Replicon: chromosome
• Accession: NZ_CP034369
• Organism: Pseudomonas aeruginosa strain SP4371

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0D0R3P1
• Locus tag: EJA98_RS28590
• Protein ID: WP_011222050.1
• Coordinates: 6040779..6041072 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6M3UV67
• Locus tag: EJA98_RS28595
• Protein ID: WP_011222051.1
• Coordinates: 6041060..6041347 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJA98_RS28555	6036027..6036926	+	900	WP_032494864.1	class A extended-spectrum beta-lactamase VEB-9	-
EJA98_RS28560	6037660..6038850	-	1191	WP_033991588.1	tetracycline efflux MFS transporter Tet(A)	-
EJA98_RS28565	6038956..6039606	+	651	WP_000164043.1	tetracycline resistance transcriptional repressor TetR(A)	-
EJA98_RS28570	6039638..6039880	-	243	WP_000844627.1	transposase	-
EJA98_RS28580	6040309..6040494	+	186	Protein_5492	multidrug transporter	-
EJA98_RS33105	6040530..6040841	+	312	WP_052150402.1	hypothetical protein	-
EJA98_RS28590	6040779..6041072	-	294	WP_011222050.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EJA98_RS28595	6041060..6041347	-	288	WP_011222051.1	CopG family ribbon-helix-helix protein	Antitoxin
EJA98_RS28600	6041520..6041726	-	207	WP_033991586.1	hypothetical protein	-
EJA98_RS28605	6041961..6043640	+	1680	WP_000179844.1	DDE-type integrase/transposase/recombinase	-
EJA98_RS28610	6043643..6044635	+	993	WP_001381192.1	TniB family NTP-binding protein	-
EJA98_RS28615	6044604..6045104	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
EJA98_RS28625	6045232..6046071	-	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaNDM-1 / sul1 / blaVEB-1 / tet(A) / ant(3'')-Ia / blaOXA-10	-	6011840..6104775	92935

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10890.71 Da
• Isoelectric Point: 10.8518

>T115800 WP_011222050.1 NZ_CP034369:c6041072-6040779 [Pseudomonas aeruginosa]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Nucleotide

• Length: 294 bp

>T115800 NZ_CP034369:c6041072-6040779 [Pseudomonas aeruginosa]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCAGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTCATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10922.19 Da
• Isoelectric Point: 5.1897

>AT115800 WP_011222051.1 NZ_CP034369:c6041347-6041060 [Pseudomonas aeruginosa]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEETDQWLA
GWGTEIEGGAPACHK

Nucleotide

• Length: 288 bp

>AT115800 NZ_CP034369:c6041347-6041060 [Pseudomonas aeruginosa]
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGACCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA

Structures

Toxin

• AlphaFold DB: A0A0D0R3P1

Antitoxin

• AlphaFold DB: A0A6M3UV67