Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5948423..5948928 Replicon chromosome
Accession NZ_CP034369
Organism Pseudomonas aeruginosa strain SP4371

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag EJA98_RS28120 Protein ID WP_031640969.1
Coordinates 5948647..5948928 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EJA98_RS28115 Protein ID WP_003083775.1
Coordinates 5948423..5948650 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJA98_RS28090 5943442..5944935 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
EJA98_RS28095 5945104..5946531 + 1428 WP_003083784.1 GABA permease -
EJA98_RS28100 5946613..5946954 - 342 WP_003101229.1 alkylphosphonate utilization protein -
EJA98_RS28105 5947026..5947526 - 501 WP_003101228.1 LEA type 2 family protein -
EJA98_RS28110 5947627..5948247 + 621 WP_003101226.1 hypothetical protein -
EJA98_RS28115 5948423..5948650 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EJA98_RS28120 5948647..5948928 + 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
EJA98_RS28125 5949228..5950136 + 909 WP_033990895.1 LysR family transcriptional regulator -
EJA98_RS28130 5950168..5950554 - 387 WP_003083767.1 aegerolysin family protein -
EJA98_RS28135 5950758..5951491 - 734 Protein_5407 GntR family transcriptional regulator -
EJA98_RS28140 5951592..5952278 - 687 WP_003083762.1 FadR family transcriptional regulator -
EJA98_RS28145 5952327..5953676 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T115799 WP_031640969.1 NZ_CP034369:5948647-5948928 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T115799 NZ_CP034369:5948647-5948928 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGAACCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT115799 WP_003083775.1 NZ_CP034369:5948423-5948650 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT115799 NZ_CP034369:5948423-5948650 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References