Detailed information of TA system TA115791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2352147..2352694
• Replicon: chromosome
• Accession: NZ_CP034367
• Organism: Halomonas venusta strain MA-ZP17-13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EI420_RS11190
• Protein ID: WP_125748704.1
• Coordinates: 2352147..2352449 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EI420_RS11195
• Protein ID: WP_125748707.1
• Coordinates: 2352437..2352694 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EI420_RS11160	2347784..2348272	-	489	WP_125748685.1	VOC family protein	-
EI420_RS11165	2348396..2349187	-	792	WP_125748688.1	type I methionyl aminopeptidase	-
EI420_RS11170	2349180..2349386	-	207	WP_125748691.1	ParD-like family protein	-
EI420_RS11175	2349564..2350778	-	1215	WP_125748694.1	winged helix-turn-helix domain-containing protein	-
EI420_RS11180	2350870..2351274	-	405	WP_125748698.1	DUF1801 domain-containing protein	-
EI420_RS11185	2351357..2351944	-	588	WP_125748701.1	class I SAM-dependent methyltransferase	-
EI420_RS11190	2352147..2352449	-	303	WP_125748704.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EI420_RS11195	2352437..2352694	-	258	WP_125748707.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EI420_RS11200	2352874..2352960	-	87	Protein_2184	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
EI420_RS11205	2353054..2353875	+	822	WP_125748710.1	aldo/keto reductase	-
EI420_RS11215	2354054..2354959	-	906	WP_125748712.1	DMT family transporter	-
EI420_RS11220	2355128..2356009	+	882	WP_022520598.1	helix-turn-helix domain-containing protein	-
EI420_RS11225	2356155..2356340	-	186	WP_205739083.1	hypothetical protein	-
EI420_RS11230	2356417..2356887	-	471	WP_125748715.1	GNAT family N-acetyltransferase	-
EI420_RS11235	2356955..2357230	-	276	WP_205739084.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11648.35 Da
• Isoelectric Point: 4.5447

>T115791 WP_125748704.1 NZ_CP034367:c2352449-2352147 [Halomonas venusta]
MAEVIWTEPALQELDAIAEYIALDNPAAASHLVQNVFDKTERLENFPRSGRIPPELPNSVYREIVVPPCRIFYREDEKQV
LILYVMREERQLRAYMLGNS

Nucleotide

• Length: 303 bp

>T115791 NZ_CP034367:c2352449-2352147 [Halomonas venusta]
ATGGCTGAAGTAATTTGGACAGAGCCTGCCCTTCAAGAACTGGATGCCATCGCTGAGTACATTGCTCTGGATAATCCTGC
TGCCGCAAGCCATCTGGTCCAAAACGTTTTCGATAAGACCGAGCGTTTGGAAAATTTCCCCCGATCTGGACGGATTCCTC
CTGAGCTCCCCAATTCGGTATACAGGGAGATAGTGGTTCCACCCTGTCGCATTTTTTATCGTGAGGATGAGAAACAGGTT
CTGATCCTTTATGTTATGCGAGAGGAGCGGCAGCTTCGTGCGTACATGCTTGGGAATAGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9871.46 Da
• Isoelectric Point: 9.5103

>AT115791 WP_125748707.1 NZ_CP034367:c2352694-2352437 [Halomonas venusta]
MKVELVTNLKRQATKILADLHLSKEPVLITEHGKPSAYLVDVQDYEFMQRRLELLEGLARGERAVLEGRTYSQSEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT115791 NZ_CP034367:c2352694-2352437 [Halomonas venusta]
ATGAAAGTTGAACTTGTTACCAACCTTAAGCGCCAAGCCACAAAAATCTTGGCAGACCTGCATCTTTCGAAAGAGCCGGT
ACTGATCACTGAACATGGCAAGCCATCCGCATACCTTGTCGATGTGCAAGATTATGAGTTTATGCAGCGCCGACTAGAGC
TGCTTGAGGGGCTTGCGCGGGGAGAGCGCGCTGTACTTGAGGGAAGAACGTACAGCCAAAGTGAGGCCAGGGAGAAAATG
AGTAAATGGCTGAAGTAA