Detailed information of TA system TA115790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1122476..1123120
• Replicon: chromosome
• Accession: NZ_CP034367
• Organism: Halomonas venusta strain MA-ZP17-13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EI420_RS05285
• Protein ID: WP_125746405.1
• Coordinates: 1122938..1123120 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EI420_RS05280
• Protein ID: WP_125746403.1
• Coordinates: 1122476..1122895 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EI420_RS05250	1117664..1118536	+	873	WP_125746393.1	hypothetical protein	-
EI420_RS05255	1118571..1118699	-	129	Protein_1030	DUF4113 domain-containing protein	-
EI420_RS05260	1118825..1119175	+	351	WP_125746395.1	hypothetical protein	-
EI420_RS05265	1119428..1120552	+	1125	WP_125746397.1	nucleoid-associated protein	-
EI420_RS05270	1120559..1121779	+	1221	WP_125746399.1	hypothetical protein	-
EI420_RS05275	1122021..1122401	+	381	WP_125746401.1	hypothetical protein	-
EI420_RS05280	1122476..1122895	-	420	WP_125746403.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EI420_RS05285	1122938..1123120	-	183	WP_125746405.1	type II toxin-antitoxin system HicA family toxin	Toxin
EI420_RS05290	1123219..1124184	-	966	WP_125746407.1	phage late control D family protein	-
EI420_RS05295	1124185..1124634	-	450	WP_125746409.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1107235..1149239	42004

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6671.76 Da
• Isoelectric Point: 10.9941

>T115790 WP_125746405.1 NZ_CP034367:c1123120-1122938 [Halomonas venusta]
VNSRALIKELEADGWELVRVKGSHHHFRHPTKPGTVTVPHPKKDLKTGLEKGIRKSAGLL

Nucleotide

• Length: 183 bp

>T115790 NZ_CP034367:c1123120-1122938 [Halomonas venusta]
GTGAACAGCAGAGCACTGATCAAGGAACTGGAAGCGGATGGCTGGGAGTTAGTGAGAGTCAAAGGCAGCCACCACCATTT
CAGGCACCCTACTAAGCCAGGCACAGTGACCGTGCCACATCCCAAAAAGGATCTGAAAACAGGGCTAGAAAAGGGAATCA
GAAAAAGCGCCGGCCTCTTATGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15227.18 Da
• Isoelectric Point: 4.3899

>AT115790 WP_125746403.1 NZ_CP034367:c1122895-1122476 [Halomonas venusta]
MLFPIAIERGDEQHAYGVAVPDLPGCHSAGDTFEEAMTNAKEAIEGWLEVAVDFGDPIPEATSIEHHMDNPDFEGWIWAV
IDIDLTPYLGKSHKINVTLPDLLVKQIDDFVASHPGDKTRSGFLSRVAMAELAKARKSA

Nucleotide

• Length: 420 bp

>AT115790 NZ_CP034367:c1122895-1122476 [Halomonas venusta]
ATGTTGTTTCCCATTGCAATTGAACGCGGCGACGAACAACACGCCTACGGCGTGGCGGTGCCTGATTTGCCCGGCTGCCA
TTCAGCGGGCGATACCTTTGAAGAAGCGATGACCAACGCAAAGGAAGCCATTGAAGGTTGGCTAGAAGTCGCCGTGGACT
TCGGCGACCCCATTCCCGAAGCCACCTCCATCGAACACCACATGGATAACCCCGATTTTGAAGGCTGGATCTGGGCTGTG
ATCGATATCGACCTAACCCCCTACCTGGGCAAAAGCCACAAAATCAACGTCACATTGCCAGACCTACTGGTTAAACAGAT
TGACGACTTTGTCGCCAGCCACCCAGGGGATAAAACGCGAAGCGGCTTCCTCTCGCGGGTTGCCATGGCAGAGCTGGCCA
AAGCACGTAAAAGCGCATAA