Detailed information of TA system TA115789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 705089..705599
• Replicon: chromosome
• Accession: NZ_CP034367
• Organism: Halomonas venusta strain MA-ZP17-13

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3S8YP06
• Locus tag: EI420_RS03340
• Protein ID: WP_030069596.1
• Coordinates: 705336..705599 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EI420_RS03335
• Protein ID: WP_125745710.1
• Coordinates: 705089..705343 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EI420_RS03310	701050..701916	+	867	WP_125745702.1	hypothetical protein	-
EI420_RS03315	702198..703049	+	852	WP_125745704.1	GNAT family N-acetyltransferase	-
EI420_RS03320	703132..703665	+	534	WP_125745706.1	AAA family ATPase	-
EI420_RS03325	703892..704272	+	381	WP_125753443.1	GFA family protein	-
EI420_RS03330	704385..704927	+	543	WP_125745708.1	DinB family protein	-
EI420_RS03335	705089..705343	+	255	WP_125745710.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EI420_RS03340	705336..705599	+	264	WP_030069596.1	Txe/YoeB family addiction module toxin	Toxin
EI420_RS03345	705646..706608	+	963	WP_125745712.1	ribonuclease Z	-
EI420_RS03350	706783..707979	-	1197	WP_125745714.1	homoserine O-acetyltransferase	-
EI420_RS03355	708055..709227	-	1173	WP_125745716.1	UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase	-
EI420_RS03360	709343..710191	+	849	WP_125745718.1	NAD-dependent protein deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10371.70 Da
• Isoelectric Point: 8.8660

>T115789 WP_030069596.1 NZ_CP034367:705336-705599 [Halomonas venusta]
MSSRLLSWTDESWSDYLYWQTQDKKTLKRINKLINDARRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDNAITI
ISCRYHY

Nucleotide

• Length: 264 bp

>T115789 NZ_CP034367:705336-705599 [Halomonas venusta]
ATGAGTAGTCGTTTACTGTCATGGACTGACGAATCCTGGAGCGATTACCTGTATTGGCAAACCCAGGACAAAAAAACGCT
GAAACGAATAAACAAGCTTATAAACGACGCTAGGCGTTCACCCTTTGAAGGTATTGGTAAACCAGAGCCGTTAAAGGAAA
ACTTAGCTGGTTTTTGGTCGCGACGTATAGATGATACGAATCGATTAGTCTACGCCGTTGATGATAATGCGATTACGATC
ATTTCGTGTCGTTATCACTATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9492.68 Da
• Isoelectric Point: 5.0733

>AT115789 WP_125745710.1 NZ_CP034367:705089-705343 [Halomonas venusta]
MKIVSFTEARNSLKTVLDSVVNDADTAVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIEQFKAGKVTHRD
LIDE

Nucleotide

• Length: 255 bp

>AT115789 NZ_CP034367:705089-705343 [Halomonas venusta]
ATGAAAATTGTGTCTTTTACAGAAGCAAGAAATAGTTTGAAAACGGTATTAGATTCCGTTGTTAATGACGCGGATACAGC
GGTGATTACTCGCCGTGATTCGGAAGATGCTGTTGTTATGTCGCTAGACTACTACAACAGTCTGATGGAAACGGTGCACT
TACTGCGCTCACCAGCGAATGCTGAACATTTGAATCGTTCAATAGAACAATTCAAAGCAGGTAAGGTAACCCACAGAGAC
TTGATTGATGAGTAG

Structures

Toxin

• AlphaFold DB: A0A3S8YP06