Detailed information of TA system TA115787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 2271360..2272003
• Replicon: chromosome
• Accession: NZ_CP034363
• Organism: Pantoea sp. CCBC3-3-1

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: EHV07_RS10650
• Protein ID: WP_147197713.1
• Coordinates: 2271360..2271776 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: EHV07_RS10655
• Protein ID: WP_147197715.1
• Coordinates: 2271773..2272003 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHV07_RS10625	2266682..2267383	-	702	WP_147197706.1	substrate-binding domain-containing protein	-
EHV07_RS10630	2267538..2268764	-	1227	WP_147197708.1	alpha-hydroxy-acid oxidizing protein	-
EHV07_RS10635	2268995..2269657	+	663	WP_147197709.1	aspartate/glutamate racemase family protein	-
EHV07_RS10640	2269661..2270980	+	1320	WP_147197711.1	four-carbon acid sugar kinase family protein	-
EHV07_RS10650	2271360..2271776	-	417	WP_147197713.1	type II toxin-antitoxin system VapC family toxin	Toxin
EHV07_RS10655	2271773..2272003	-	231	WP_147197715.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
EHV07_RS10660	2272058..2272267	+	210	WP_147197717.1	hypothetical protein	-
EHV07_RS10665	2272392..2273285	-	894	WP_147197719.1	SDR family oxidoreductase	-
EHV07_RS10670	2273363..2274046	-	684	WP_147197721.1	two-component system response regulator KdpE	-
EHV07_RS10675	2274018..2276720	-	2703	WP_147197723.1	two-component system sensor histidine kinase KdpD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15036.34 Da
• Isoelectric Point: 5.7261

>T115787 WP_147197713.1 NZ_CP034363:c2271776-2271360 [Pantoea sp. CCBC3-3-1]
VNNTYMLDTCICSFIMREQPEAVLKRLEQAVLRNQRIVVSAITYSEMRFGATGPKASPRHMGLVDAFCARLDAILPWDRA
AVDATTDIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWAE

Nucleotide

• Length: 417 bp

>T115787 NZ_CP034363:c2271776-2271360 [Pantoea sp. CCBC3-3-1]
GTGAACAACACCTATATGCTTGACACCTGTATCTGCTCGTTCATCATGCGCGAACAGCCGGAAGCCGTACTAAAGCGCCT
GGAGCAGGCAGTGCTGCGTAATCAGCGTATCGTTGTCTCGGCCATTACCTATTCGGAGATGCGCTTCGGTGCCACTGGCC
CGAAGGCCTCGCCGCGCCACATGGGGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCGGTGGACGCCACCACGGATATTAAGGTGGCACTTCGACTGGCCGGCACGCCAATCGGCCCGAACGACACGGCGATCGC
CGGGCATGCGATTGCGGCAGGGGCGATTCTGGTGACAAATAACACGCGGGAGTTTGAGCGGGTACCGGGTCTGGTGCTGG
AAGACTGGGCGGAGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8698.75 Da
• Isoelectric Point: 4.3654

>AT115787 WP_147197715.1 NZ_CP034363:c2272003-2271773 [Pantoea sp. CCBC3-3-1]
MRTVSIFKNGNNRAIRLPRDLDFEGASELEIIREGDSIILRPVRPTWSSFASLEKADPDFMAEREDVVSDEGRFDL

Nucleotide

• Length: 231 bp

>AT115787 NZ_CP034363:c2272003-2271773 [Pantoea sp. CCBC3-3-1]
ATGCGCACAGTTTCTATTTTTAAAAACGGCAACAATCGCGCCATCCGTCTGCCCCGGGATCTGGATTTTGAGGGAGCAAG
CGAGCTGGAGATTATCCGGGAAGGAGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGAGCTCGTTTGCCAGCCTGG
AAAAGGCCGACCCGGACTTTATGGCAGAGCGCGAAGACGTTGTTAGCGACGAAGGACGATTTGACCTGTGA