Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1266522..1267152 Replicon chromosome
Accession NZ_CP034363
Organism Pantoea sp. CCBC3-3-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EHV07_RS05875 Protein ID WP_147195990.1
Coordinates 1266522..1266698 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EHV07_RS05880 Protein ID WP_147195992.1
Coordinates 1266745..1267152 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHV07_RS05815 1261677..1261955 + 279 WP_147195963.1 hypothetical protein -
EHV07_RS05820 1261952..1262131 + 180 WP_147195965.1 hypothetical protein -
EHV07_RS05825 1262135..1262581 + 447 WP_147195969.1 hypothetical protein -
EHV07_RS05830 1262581..1262955 + 375 WP_147200539.1 ASCH domain-containing protein -
EHV07_RS05835 1262964..1263551 + 588 WP_147195973.1 S-adenosylmethionine-binding protein -
EHV07_RS05840 1263548..1263835 + 288 WP_147195975.1 hypothetical protein -
EHV07_RS05845 1263819..1263989 + 171 WP_147195978.1 NinE family protein -
EHV07_RS05850 1263986..1264183 + 198 WP_168199597.1 hypothetical protein -
EHV07_RS05855 1264378..1264953 + 576 WP_147195982.1 recombination protein NinG -
EHV07_RS05860 1265123..1265737 + 615 WP_147195984.1 hypothetical protein -
EHV07_RS05870 1266030..1266236 - 207 WP_147195988.1 hypothetical protein -
EHV07_RS05875 1266522..1266698 + 177 WP_147195990.1 type II toxin-antitoxin system HicA family toxin Toxin
EHV07_RS05880 1266745..1267152 + 408 WP_147195992.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EHV07_RS05885 1267381..1267731 + 351 WP_147200540.1 phage holin, lambda family -
EHV07_RS05890 1267718..1268155 + 438 WP_147195994.1 lysozyme -
EHV07_RS05900 1268444..1268740 + 297 WP_168199598.1 peptidase -
EHV07_RS05905 1268744..1268980 + 237 WP_147196001.1 hypothetical protein -
EHV07_RS05915 1269255..1270142 + 888 WP_147196003.1 hypothetical protein -
EHV07_RS05920 1270150..1270401 + 252 WP_147196005.1 hypothetical protein -
EHV07_RS05925 1270391..1270771 + 381 WP_147196007.1 hypothetical protein -
EHV07_RS05930 1270899..1271345 - 447 WP_147196009.1 hypothetical protein -
EHV07_RS05935 1271366..1271938 + 573 WP_147196011.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - acrB / acrA 1179950..1310593 130643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6709.87 Da        Isoelectric Point: 10.8214

>T115785 WP_147195990.1 NZ_CP034363:1266522-1266698 [Pantoea sp. CCBC3-3-1]
VKQSEFQRWLAAQGAEFKNGTNHLKIYLNDKQTIMPRHPGKEIPEPLRKAILKQLGLK

Download         Length: 177 bp

>T115785 NZ_CP034363:1266522-1266698 [Pantoea sp. CCBC3-3-1]
GTGAAGCAAAGCGAGTTTCAACGTTGGCTTGCAGCGCAAGGGGCAGAATTTAAGAACGGCACAAACCACCTTAAAATCTA
CCTGAACGACAAGCAGACGATAATGCCGAGGCATCCGGGGAAGGAAATACCGGAGCCGCTGAGAAAAGCGATTCTCAAGC
AACTCGGTCTTAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14631.65 Da        Isoelectric Point: 4.2606

>AT115785 WP_147195992.1 NZ_CP034363:1266745-1267152 [Pantoea sp. CCBC3-3-1]
MRYPVTLDCDDTGCAVLFPDIPEAVTGGDTREEALAMAQDALVTAFDFYFEDRREVPPPSSEGEAFVEVPASVAAKVLLL
NAVVQAGVTNAELARMIDTRPQEITRVFDLHHSTKIDTIQKALSALGKRLELAAV

Download         Length: 408 bp

>AT115785 NZ_CP034363:1266745-1267152 [Pantoea sp. CCBC3-3-1]
ATGAGATACCCAGTAACATTAGATTGTGACGATACGGGATGCGCAGTGCTGTTTCCTGACATCCCGGAAGCGGTGACGGG
CGGCGATACCAGAGAAGAGGCGTTAGCAATGGCGCAAGACGCTCTGGTAACTGCATTTGATTTCTATTTTGAAGATCGTC
GTGAAGTGCCGCCGCCATCGTCAGAGGGTGAGGCTTTTGTAGAAGTGCCGGCAAGCGTAGCTGCCAAGGTGCTTTTGCTC
AATGCCGTGGTTCAGGCTGGCGTAACCAACGCCGAGCTGGCCCGCATGATAGATACGCGCCCGCAAGAGATTACACGGGT
GTTTGATCTGCATCACTCGACCAAAATCGACACTATCCAGAAGGCGCTATCGGCGCTGGGCAAGCGGCTGGAACTGGCCG
CTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References