Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3246564..3247069 Replicon chromosome
Accession NZ_CP034354
Organism Pseudomonas aeruginosa strain IMP-13

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag EIP87_RS15480 Protein ID WP_003121619.1
Coordinates 3246564..3246845 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag EIP87_RS15485 Protein ID WP_003112628.1
Coordinates 3246842..3247069 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIP87_RS15455 3241815..3243164 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
EIP87_RS15460 3243213..3243899 + 687 WP_003083762.1 FadR family transcriptional regulator -
EIP87_RS15465 3244000..3244734 + 735 WP_043095998.1 GntR family transcriptional regulator -
EIP87_RS15470 3244938..3245324 + 387 WP_014602345.1 aegerolysin family protein -
EIP87_RS15475 3245356..3246264 - 909 WP_016561475.1 LysR family transcriptional regulator -
EIP87_RS15480 3246564..3246845 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
EIP87_RS15485 3246842..3247069 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
EIP87_RS15490 3247245..3247865 - 621 WP_003101226.1 hypothetical protein -
EIP87_RS15495 3247966..3248466 + 501 WP_003101228.1 LEA type 2 family protein -
EIP87_RS15500 3248539..3248880 + 342 WP_003101229.1 alkylphosphonate utilization protein -
EIP87_RS15505 3248962..3250389 - 1428 WP_003083784.1 GABA permease -
EIP87_RS15510 3250558..3252051 - 1494 WP_043095997.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T115776 WP_003121619.1 NZ_CP034354:c3246845-3246564 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T115776 NZ_CP034354:c3246845-3246564 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT115776 WP_003112628.1 NZ_CP034354:c3247069-3246842 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT115776 NZ_CP034354:c3247069-3246842 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References