115774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 1431954..1432562 Replicon chromosome
Accession NZ_CP034354
Organism Pseudomonas aeruginosa strain IMP-13

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag EIP87_RS07020 Protein ID WP_003114156.1
Coordinates 1431954..1432301 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag EIP87_RS07025 Protein ID WP_003114155.1
Coordinates 1432311..1432562 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIP87_RS07000 1426980..1428011 + 1032 WP_003158906.1 AAA family ATPase -
EIP87_RS07005 1427989..1430499 + 2511 WP_003160813.1 S8 family peptidase -
EIP87_RS07010 1430598..1430903 - 306 WP_003158903.1 helix-turn-helix domain-containing protein -
EIP87_RS07015 1431025..1431666 + 642 WP_003158902.1 substrate-binding domain-containing protein -
EIP87_RS07020 1431954..1432301 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EIP87_RS07025 1432311..1432562 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EIP87_RS07030 1432776..1433759 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
EIP87_RS07035 1433759..1435051 - 1293 WP_003115206.1 hypothetical protein -
EIP87_RS07040 1435281..1436555 - 1275 WP_043096062.1 zonular occludens toxin family protein -
EIP87_RS07045 1436559..1436915 - 357 WP_003114150.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaIMP-13 / sul1 - 1343196..1445611 102415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T115774 WP_003114156.1 NZ_CP034354:c1432301-1431954 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T115774 NZ_CP034354:c1432301-1431954 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT115774 WP_003114155.1 NZ_CP034354:c1432562-1432311 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT115774 NZ_CP034354:c1432562-1432311 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References