115772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 3307877..3308415 Replicon chromosome
Accession NZ_CP034350
Organism Streptomyces sp. W1SF4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D1J60_RS15255 Protein ID WP_125821470.1
Coordinates 3307877..3308131 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag D1J60_RS15260 Protein ID WP_206436530.1
Coordinates 3308128..3308415 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1J60_RS15235 3303931..3304278 + 348 WP_125821467.1 hypothetical protein -
D1J60_RS15240 3304718..3306265 + 1548 WP_125821468.1 alkaline phosphatase -
D1J60_RS15245 3306349..3306909 + 561 WP_125821469.1 hypothetical protein -
D1J60_RS15250 3307001..3307798 + 798 WP_125824045.1 VOC family protein -
D1J60_RS15255 3307877..3308131 - 255 WP_125821470.1 Txe/YoeB family addiction module toxin Toxin
D1J60_RS15260 3308128..3308415 - 288 WP_206436530.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
D1J60_RS15265 3308586..3310976 - 2391 WP_125821471.1 tetratricopeptide repeat protein -
D1J60_RS15270 3310973..3311335 - 363 WP_125821472.1 hypothetical protein -
D1J60_RS15275 3311410..3311928 - 519 WP_125821473.1 hypothetical protein -
D1J60_RS15280 3312030..3312395 - 366 WP_125824046.1 ATP-binding protein -
D1J60_RS15285 3312536..3313360 + 825 WP_125821474.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10006.44 Da        Isoelectric Point: 10.3790

>T115772 WP_125821470.1 NZ_CP034350:c3308131-3307877 [Streptomyces sp. W1SF4]
MKVVFSGRAWDQYTYWATADPKILKRVNRLIKEIQRTPFEGAGKPEPLKENLSGWWSRRITDEHRLVYRVRDGAVEVAQA
RYHY

Download         Length: 255 bp

>T115772 NZ_CP034350:c3308131-3307877 [Streptomyces sp. W1SF4]
TTGAAGGTCGTCTTCTCGGGACGGGCCTGGGACCAGTACACGTACTGGGCGACGGCCGACCCGAAGATCCTAAAGAGGGT
CAACCGCCTGATCAAGGAAATCCAGCGCACGCCGTTCGAGGGCGCGGGAAAACCGGAGCCGCTCAAGGAGAACCTGTCCG
GCTGGTGGTCCCGGAGGATCACCGACGAGCACCGGCTCGTGTACCGCGTCAGGGACGGTGCCGTGGAAGTCGCGCAGGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10713.78 Da        Isoelectric Point: 4.1468

>AT115772 WP_206436530.1 NZ_CP034350:c3308415-3308128 [Streptomyces sp. W1SF4]
VPISANEARQRFYPLIRQVNEDHVPIEVTSREHGDVVIMSAEDFRSWQETVYLLRSPRNAQILMESIAELDAGHGQAREL
IGEDEDEPEAEGSAP

Download         Length: 288 bp

>AT115772 NZ_CP034350:c3308415-3308128 [Streptomyces sp. W1SF4]
GTGCCGATCTCGGCCAACGAGGCCCGGCAGCGTTTCTACCCGCTGATCCGGCAGGTCAACGAGGATCACGTGCCCATAGA
GGTCACTTCCAGGGAGCACGGCGACGTCGTGATCATGTCCGCCGAGGACTTCCGGTCCTGGCAGGAGACCGTCTACCTGC
TGCGCTCGCCGCGCAACGCGCAGATCCTGATGGAGTCCATCGCGGAGCTGGACGCCGGCCACGGCCAGGCCCGGGAGCTG
ATCGGCGAGGACGAGGACGAGCCCGAAGCCGAGGGGTCCGCCCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References