115771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2924855..2925387 Replicon chromosome
Accession NZ_CP034350
Organism Streptomyces sp. W1SF4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D1J60_RS13595 Protein ID WP_125601863.1
Coordinates 2925124..2925387 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D1J60_RS13590 Protein ID WP_125601867.1
Coordinates 2924855..2925127 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1J60_RS13575 2920711..2921679 - 969 WP_125821278.1 LysR family transcriptional regulator -
D1J60_RS13580 2922097..2923194 + 1098 WP_125824010.1 MFS transporter -
D1J60_RS13585 2923289..2924716 + 1428 WP_125821279.1 SH3 domain-containing protein -
D1J60_RS13590 2924855..2925127 + 273 WP_125601867.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
D1J60_RS13595 2925124..2925387 + 264 WP_125601863.1 Txe/YoeB family addiction module toxin Toxin
D1J60_RS13605 2925922..2926407 - 486 WP_007264411.1 SsrA-binding protein SmpB -
D1J60_RS13610 2926426..2927622 - 1197 WP_125821280.1 PDZ domain-containing protein -
D1J60_RS13615 2927690..2928679 - 990 WP_125821281.1 permease-like cell division protein FtsX -
D1J60_RS13620 2928697..2929386 - 690 WP_007264414.1 cell division ATP-binding protein FtsE -
D1J60_RS13625 2929615..2929803 + 189 WP_125601854.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-71)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10321.72 Da        Isoelectric Point: 8.4388

>T115771 WP_125601863.1 NZ_CP034350:2925124-2925387 [Streptomyces sp. W1SF4]
VRSVHFDPDAWEDFLYWLAADRKMAKRITRLIGEVQRAPFEGIGKPEALKGDLSGYWSRRIDDEHRLVYRADDKEVKILK
ARYHYAD

Download         Length: 264 bp

>T115771 NZ_CP034350:2925124-2925387 [Streptomyces sp. W1SF4]
GTGAGGAGCGTCCACTTCGACCCGGACGCCTGGGAGGACTTCCTCTACTGGCTCGCCGCGGACCGGAAGATGGCCAAGCG
CATCACCCGCCTGATCGGCGAAGTCCAGCGGGCACCCTTCGAGGGCATCGGGAAACCGGAAGCGCTCAAGGGCGACCTGT
CCGGCTACTGGTCCCGCCGGATCGACGACGAGCACCGGCTCGTCTACCGGGCCGACGACAAGGAAGTGAAGATCCTCAAG
GCCCGCTACCACTACGCCGACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9948.17 Da        Isoelectric Point: 4.8096

>AT115771 WP_125601867.1 NZ_CP034350:2924855-2925127 [Streptomyces sp. W1SF4]
MPISASEARKTLFPLIERVNNDHTPVRISSKNGDAVLMSAEDYDSWQETVYLLRSPANARRLMEAVARDRQGTAGIAKSM
DELNALAGEE

Download         Length: 273 bp

>AT115771 NZ_CP034350:2924855-2925127 [Streptomyces sp. W1SF4]
ATGCCCATAAGCGCCAGCGAAGCCCGCAAGACCCTCTTCCCCCTGATCGAGCGCGTCAACAACGACCACACCCCGGTGCG
CATCAGCTCCAAGAACGGCGACGCCGTCCTGATGTCGGCCGAGGACTACGACTCCTGGCAGGAGACCGTCTACCTGCTGC
GCTCGCCGGCGAACGCCCGCCGCCTCATGGAGGCCGTCGCGCGCGACCGGCAGGGCACGGCCGGCATCGCCAAGAGCATG
GACGAGCTGAACGCGCTGGCCGGTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References