Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2046059..2046573 Replicon chromosome
Accession NZ_CP034349
Organism Staphylococcus aureus strain 80wphwpl

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag C6567_RS10225 Protein ID WP_000581791.1
Coordinates 2046059..2046268 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag C6567_RS10230 Protein ID WP_000138934.1
Coordinates 2046280..2046573 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6567_RS10200 2041418..2042620 + 1203 WP_001109940.1 rod shape-determining protein RodA -
C6567_RS10205 2042714..2042990 - 277 Protein_1893 transposase -
C6567_RS10210 2043051..2044697 - 1647 WP_000277741.1 IS1182-like element ISSau3 family transposase -
C6567_RS10215 2044976..2045382 - 407 Protein_1895 transposase -
C6567_RS10220 2045794..2045931 - 138 WP_000828354.1 hypothetical protein -
C6567_RS10225 2046059..2046268 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
C6567_RS10230 2046280..2046573 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
C6567_RS10235 2046739..2048223 + 1485 WP_000571560.1 cardiolipin synthase -
C6567_RS10240 2048251..2048898 + 648 WP_001187612.1 HD domain-containing protein -
C6567_RS10255 2049513..2050385 - 873 WP_000725802.1 membrane protein insertase YidC -
C6567_RS10260 2050471..2051112 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T115764 WP_000581791.1 NZ_CP034349:c2046268-2046059 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T115764 NZ_CP034349:c2046268-2046059 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT115764 WP_000138934.1 NZ_CP034349:c2046573-2046280 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT115764 NZ_CP034349:c2046573-2046280 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References