Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5275841..5276490 Replicon chromosome
Accession NZ_CP034338
Organism Pseudomonas entomophila strain 1257

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EJA05_RS24625 Protein ID WP_125465620.1
Coordinates 5276308..5276490 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EJA05_RS24620 Protein ID WP_125860476.1
Coordinates 5275841..5276251 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJA05_RS24595 5271846..5272751 - 906 WP_125860466.1 LysR family transcriptional regulator -
EJA05_RS24600 5272889..5273479 - 591 WP_125860468.1 NAD(P)H-dependent oxidoreductase -
EJA05_RS24605 5273657..5273971 + 315 WP_125860470.1 antibiotic biosynthesis monooxygenase -
EJA05_RS24610 5273961..5274725 - 765 WP_125860472.1 sulfite exporter TauE/SafE family protein -
EJA05_RS24615 5274803..5275687 + 885 WP_125860474.1 LysR family transcriptional regulator -
EJA05_RS24620 5275841..5276251 - 411 WP_125860476.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EJA05_RS24625 5276308..5276490 - 183 WP_125465620.1 type II toxin-antitoxin system HicA family toxin Toxin
EJA05_RS24630 5276704..5277309 + 606 WP_125860478.1 CDP-alcohol phosphatidyltransferase family protein -
EJA05_RS24635 5277340..5279094 + 1755 WP_125860480.1 bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase -
EJA05_RS24640 5279094..5280497 + 1404 WP_125860482.1 phosphatase PAP2/dual specificity phosphatase family protein -
EJA05_RS24645 5280494..5280913 + 420 WP_125860483.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6942.97 Da        Isoelectric Point: 10.7251

>T115757 WP_125465620.1 NZ_CP034338:c5276490-5276308 [Pseudomonas entomophila]
MRSRDVIQLIEADGWYEVEVKGSHHQFRHPYKRGRVTVPHPKSDLPRGTVHSILKQAGLK

Download         Length: 183 bp

>T115757 NZ_CP034338:c5276490-5276308 [Pseudomonas entomophila]
ATGCGCAGCAGGGACGTGATCCAGCTCATCGAGGCTGATGGTTGGTACGAGGTGGAAGTGAAAGGAAGTCACCATCAATT
CAGGCATCCGTACAAGCGAGGGCGGGTCACGGTTCCCCATCCCAAAAGCGATCTACCCAGGGGCACCGTGCACAGCATTT
TGAAACAGGCTGGCTTGAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14737.65 Da        Isoelectric Point: 4.6138

>AT115757 WP_125860476.1 NZ_CP034338:c5276251-5275841 [Pseudomonas entomophila]
MKFPVVLHKDEGTDYGVIVPDVPGCFSAGATVSQALENVQEALALHFEGLVADGEALPQAEEVDVHVANPDYAGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELAVAFR

Download         Length: 411 bp

>AT115757 NZ_CP034338:c5276251-5275841 [Pseudomonas entomophila]
ATGAAATTTCCCGTTGTACTGCATAAGGATGAGGGCACTGACTACGGCGTGATCGTGCCCGACGTGCCTGGCTGTTTCTC
GGCCGGCGCCACTGTTTCCCAGGCGCTGGAGAATGTGCAGGAAGCGCTGGCCCTGCATTTCGAAGGCCTGGTGGCCGACG
GCGAGGCGCTGCCGCAGGCCGAGGAGGTGGATGTGCATGTGGCCAATCCCGACTACGCCGGGGGCGTCTGGGCGGTGGTG
GACTTCGATGTCACCCCGTACCTGGGCAAGGCGGTGCGCTTCAATGCCACGTTGCCCGAGAACCTGCTGCAGCGCATCGA
CGAAAAGGTGAAACGCGATCATCGTTATGCCTCGCGCTCTGGCTTCCTCGCCTCGGCTGCGCTGCGCGAGCTGGCGGTCG
CCTTCCGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References