Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1267004..1267632 Replicon chromosome
Accession NZ_CP034338
Organism Pseudomonas entomophila strain 1257

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EJA05_RS05995 Protein ID WP_125857637.1
Coordinates 1267004..1267186 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EJA05_RS06000 Protein ID WP_125857638.1
Coordinates 1267207..1267632 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJA05_RS05970 1262856..1263950 + 1095 WP_125462864.1 iron-sulfur cluster carrier protein ApbC -
EJA05_RS05975 1264179..1264388 - 210 WP_016488765.1 cold-shock protein -
EJA05_RS05980 1264729..1265295 + 567 WP_003258001.1 dCTP deaminase -
EJA05_RS05985 1265394..1265624 + 231 WP_110995504.1 hypothetical protein -
EJA05_RS05990 1265656..1266771 - 1116 WP_125857636.1 succinylglutamate desuccinylase/aspartoacylase family protein -
EJA05_RS05995 1267004..1267186 + 183 WP_125857637.1 type II toxin-antitoxin system HicA family toxin Toxin
EJA05_RS06000 1267207..1267632 + 426 WP_125857638.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EJA05_RS06005 1267687..1270122 - 2436 WP_125857639.1 penicillin acylase family protein -
EJA05_RS06010 1270311..1270514 - 204 WP_012313055.1 SEC-C domain-containing protein -
EJA05_RS06015 1270522..1270998 - 477 WP_125857640.1 LEA type 2 family protein -
EJA05_RS06020 1271001..1271477 - 477 WP_125857641.1 YchJ family protein -
EJA05_RS06025 1271482..1271976 - 495 WP_125462869.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-114)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6848.00 Da        Isoelectric Point: 10.8431

>T115752 WP_125857637.1 NZ_CP034338:1267004-1267186 [Pseudomonas entomophila]
MKYSEFRRWLRAQGATFVPAKGSHFKVYLGKRQTIFPDHGAKEIGEGLRKKILKDLGLGD

Download         Length: 183 bp

>T115752 NZ_CP034338:1267004-1267186 [Pseudomonas entomophila]
ATGAAATACAGCGAATTCCGTCGGTGGCTGCGTGCTCAAGGCGCCACGTTCGTTCCTGCCAAAGGCAGCCATTTCAAGGT
TTACCTCGGCAAACGACAGACGATCTTCCCCGACCATGGCGCCAAGGAAATTGGCGAAGGGCTCAGGAAAAAGATCCTCA
AAGACCTTGGGCTAGGCGATTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15408.81 Da        Isoelectric Point: 5.9738

>AT115752 WP_125857638.1 NZ_CP034338:1267207-1267632 [Pseudomonas entomophila]
MNFDYPVIVHCEAGSFWISCPDIPEMASAGGTMDEALFDAVDALESALSLYVDRRDAIPLPSPHGCDQAVVRLPALTAAK
AALWNTMIAQKVTKTELARRLGVNRPQVDRLVNLLHRSKIEQVEHALHVLGQRIELAVVAA

Download         Length: 426 bp

>AT115752 NZ_CP034338:1267207-1267632 [Pseudomonas entomophila]
ATGAATTTTGATTATCCGGTGATCGTGCATTGTGAAGCAGGCAGCTTCTGGATCAGCTGTCCGGATATTCCAGAAATGGC
CAGTGCGGGCGGCACGATGGATGAGGCGTTGTTCGATGCTGTCGATGCCTTGGAGTCGGCGCTTTCGTTATACGTGGATC
GGCGTGACGCGATTCCACTGCCTTCGCCACACGGATGCGATCAGGCGGTGGTCAGGTTGCCTGCGTTGACCGCCGCCAAG
GCCGCGCTGTGGAACACCATGATTGCGCAGAAAGTGACCAAGACCGAACTGGCTCGGCGACTTGGCGTCAATCGGCCACA
AGTGGATCGTCTGGTCAACCTGTTGCATCGCTCGAAGATCGAGCAGGTAGAGCACGCCTTGCATGTGTTGGGCCAGCGTA
TCGAATTGGCAGTGGTCGCTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References