Detailed information of TA system TA115748

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4914386..4915035
• Replicon: chromosome
• Accession: NZ_CP034337
• Organism: Pseudomonas entomophila strain 2014

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EI693_RS22805
• Protein ID: WP_125465620.1
• Coordinates: 4914853..4915035 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EI693_RS22800
• Protein ID: WP_125465619.1
• Coordinates: 4914386..4914796 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EI693_RS22775	4910383..4911288	-	906	WP_125465614.1	LysR family transcriptional regulator	-
EI693_RS22780	4911434..4912024	-	591	WP_125465615.1	NAD(P)H-dependent oxidoreductase	-
EI693_RS22785	4912202..4912516	+	315	WP_125465616.1	antibiotic biosynthesis monooxygenase	-
EI693_RS22790	4912506..4913270	-	765	WP_125465617.1	sulfite exporter TauE/SafE family protein	-
EI693_RS22795	4913348..4914232	+	885	WP_125465618.1	LysR family transcriptional regulator	-
EI693_RS22800	4914386..4914796	-	411	WP_125465619.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EI693_RS22805	4914853..4915035	-	183	WP_125465620.1	type II toxin-antitoxin system HicA family toxin	Toxin
EI693_RS22810	4915249..4915854	+	606	WP_125465621.1	CDP-alcohol phosphatidyltransferase family protein	-
EI693_RS22815	4915885..4917639	+	1755	WP_125465622.1	bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase	-
EI693_RS22820	4917639..4918952	+	1314	WP_125465623.1	phosphatase PAP2/dual specificity phosphatase family protein	-
EI693_RS22825	4918949..4919368	+	420	WP_125465624.1	hypothetical protein	-
EI693_RS22830	4919379..4920002	+	624	WP_125465625.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6942.97 Da
• Isoelectric Point: 10.7251

>T115748 WP_125465620.1 NZ_CP034337:c4915035-4914853 [Pseudomonas entomophila]
MRSRDVIQLIEADGWYEVEVKGSHHQFRHPYKRGRVTVPHPKSDLPRGTVHSILKQAGLK

Nucleotide

• Length: 183 bp

>T115748 NZ_CP034337:c4915035-4914853 [Pseudomonas entomophila]
ATGCGCAGCAGGGACGTGATCCAGCTCATCGAGGCTGATGGTTGGTACGAGGTGGAAGTGAAAGGAAGTCACCATCAATT
CAGGCATCCGTACAAGCGAGGGCGGGTCACGGTTCCCCATCCCAAAAGCGATCTACCCAGGGGCACCGTGCACAGCATTT
TGAAACAGGCTGGCTTGAAATGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14723.62 Da
• Isoelectric Point: 4.6138

>AT115748 WP_125465619.1 NZ_CP034337:c4914796-4914386 [Pseudomonas entomophila]
MKFPVVLHKDEGSDYGVIVPDVPGCFSAGATVSQALENVQEALALHFEGLVADGEALPQAEEVDVHVANPDYAGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELAVAFR

Nucleotide

• Length: 411 bp

>AT115748 NZ_CP034337:c4914796-4914386 [Pseudomonas entomophila]
ATGAAATTCCCCGTTGTACTGCATAAGGATGAGGGCTCGGATTACGGCGTGATCGTGCCCGACGTGCCTGGCTGCTTCTC
GGCCGGCGCTACTGTTTCCCAGGCGCTGGAGAATGTGCAGGAAGCCCTGGCCCTGCATTTCGAAGGCCTGGTGGCCGACG
GCGAGGCGCTGCCGCAGGCCGAGGAGGTGGATGTGCATGTGGCCAATCCCGACTACGCCGGGGGCGTCTGGGCGGTGGTG
GACTTCGATGTCACCCCGTACCTGGGCAAGGCGGTGCGCTTCAATGCCACGTTGCCCGAGAACCTGCTGCAGCGCATCGA
CGAAAAGGTGAAACGCGATCATCGTTATGCCTCGCGCTCTGGCTTCCTCGCCTCGGCTGCGCTGCGCGAGCTGGCGGTCG
CCTTCCGCTAG