Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4914386..4915035 Replicon chromosome
Accession NZ_CP034337
Organism Pseudomonas entomophila strain 2014

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EI693_RS22805 Protein ID WP_125465620.1
Coordinates 4914853..4915035 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EI693_RS22800 Protein ID WP_125465619.1
Coordinates 4914386..4914796 (-) Length 137 a.a.

Genomic Context

EI693_RS22785EI693_RS22795EI693_RS22810EI693_RS22815EI693_RS22820EI693_RS22825EI693_RS22830EI693_RS22775EI693_RS22780EI693_RS22790EI693_RS22800EI693_RS22805
Location: 4912202..4912516 (315 bp)
Type: Others
Protein ID: WP_125465616.1
Location: 4913348..4914232 (885 bp)
Type: Others
Protein ID: WP_125465618.1
Location: 4915249..4915854 (606 bp)
Type: Others
Protein ID: WP_125465621.1
Location: 4915885..4917639 (1755 bp)
Type: Others
Protein ID: WP_125465622.1
Location: 4917639..4918952 (1314 bp)
Type: Others
Protein ID: WP_125465623.1
Location: 4918949..4919368 (420 bp)
Type: Others
Protein ID: WP_125465624.1
Location: 4919379..4920002 (624 bp)
Type: Others
Protein ID: WP_125465625.1
Location: 4910383..4911288 (906 bp)
Type: Others
Protein ID: WP_125465614.1
Location: 4911434..4912024 (591 bp)
Type: Others
Protein ID: WP_125465615.1
Location: 4912506..4913270 (765 bp)
Type: Others
Protein ID: WP_125465617.1
Location: 4914386..4914796 (411 bp)
Type: Antitoxin
Protein ID: WP_125465619.1
Location: 4914853..4915035 (183 bp)
Type: Toxin
Protein ID: WP_125465620.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EI693_RS227754910383..4911288-906WP_125465614.1LysR family transcriptional regulator-
EI693_RS227804911434..4912024-591WP_125465615.1NAD(P)H-dependent oxidoreductase-
EI693_RS227854912202..4912516+315WP_125465616.1antibiotic biosynthesis monooxygenase-
EI693_RS227904912506..4913270-765WP_125465617.1sulfite exporter TauE/SafE family protein-
EI693_RS227954913348..4914232+885WP_125465618.1LysR family transcriptional regulator-
EI693_RS228004914386..4914796-411WP_125465619.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
EI693_RS228054914853..4915035-183WP_125465620.1type II toxin-antitoxin system HicA family toxinToxin
EI693_RS228104915249..4915854+606WP_125465621.1CDP-alcohol phosphatidyltransferase family protein-
EI693_RS228154915885..4917639+1755WP_125465622.1bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase-
EI693_RS228204917639..4918952+1314WP_125465623.1phosphatase PAP2/dual specificity phosphatase family protein-
EI693_RS228254918949..4919368+420WP_125465624.1hypothetical protein-
EI693_RS228304919379..4920002+624WP_125465625.11-acyl-sn-glycerol-3-phosphate acyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6942.97 Da        Isoelectric Point: 10.7251

>T115748 WP_125465620.1 NZ_CP034337:c4915035-4914853 [Pseudomonas entomophila]
MRSRDVIQLIEADGWYEVEVKGSHHQFRHPYKRGRVTVPHPKSDLPRGTVHSILKQAGLK

Download         Length: 183 bp

>T115748 NZ_CP034337:c4915035-4914853 [Pseudomonas entomophila]
ATGCGCAGCAGGGACGTGATCCAGCTCATCGAGGCTGATGGTTGGTACGAGGTGGAAGTGAAAGGAAGTCACCATCAATT
CAGGCATCCGTACAAGCGAGGGCGGGTCACGGTTCCCCATCCCAAAAGCGATCTACCCAGGGGCACCGTGCACAGCATTT
TGAAACAGGCTGGCTTGAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14723.62 Da        Isoelectric Point: 4.6138

>AT115748 WP_125465619.1 NZ_CP034337:c4914796-4914386 [Pseudomonas entomophila]
MKFPVVLHKDEGSDYGVIVPDVPGCFSAGATVSQALENVQEALALHFEGLVADGEALPQAEEVDVHVANPDYAGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELAVAFR

Download         Length: 411 bp

>AT115748 NZ_CP034337:c4914796-4914386 [Pseudomonas entomophila]
ATGAAATTCCCCGTTGTACTGCATAAGGATGAGGGCTCGGATTACGGCGTGATCGTGCCCGACGTGCCTGGCTGCTTCTC
GGCCGGCGCTACTGTTTCCCAGGCGCTGGAGAATGTGCAGGAAGCCCTGGCCCTGCATTTCGAAGGCCTGGTGGCCGACG
GCGAGGCGCTGCCGCAGGCCGAGGAGGTGGATGTGCATGTGGCCAATCCCGACTACGCCGGGGGCGTCTGGGCGGTGGTG
GACTTCGATGTCACCCCGTACCTGGGCAAGGCGGTGCGCTTCAATGCCACGTTGCCCGAGAACCTGCTGCAGCGCATCGA
CGAAAAGGTGAAACGCGATCATCGTTATGCCTCGCGCTCTGGCTTCCTCGCCTCGGCTGCGCTGCGCGAGCTGGCGGTCG
CCTTCCGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References