Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3613835..3614492 Replicon chromosome
Accession NZ_CP034336
Organism Enterobacter asburiae strain CAV1043

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag EI562_RS18165 Protein ID WP_021242050.1
Coordinates 3614082..3614492 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag EI562_RS18160 Protein ID WP_010435322.1
Coordinates 3613835..3614101 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EI562_RS18135 3609019..3610452 - 1434 WP_023309104.1 6-phospho-beta-glucosidase BglA -
EI562_RS18140 3610569..3611300 - 732 WP_032667928.1 MurR/RpiR family transcriptional regulator -
EI562_RS18145 3611352..3611663 + 312 WP_023309102.1 N(4)-acetylcytidine aminohydrolase -
EI562_RS18150 3611829..3612488 + 660 WP_023309101.1 hemolysin III family protein -
EI562_RS18155 3612562..3613542 - 981 WP_023309100.1 tRNA-modifying protein YgfZ -
EI562_RS18160 3613835..3614101 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
EI562_RS18165 3614082..3614492 + 411 WP_021242050.1 protein YgfX Toxin
EI562_RS18170 3614499..3615020 - 522 WP_023309099.1 flavodoxin FldB -
EI562_RS18175 3615122..3616018 + 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
EI562_RS18180 3616047..3616760 + 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EI562_RS18185 3616766..3618499 + 1734 WP_023309096.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T115732 WP_021242050.1 NZ_CP034336:3614082-3614492 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T115732 NZ_CP034336:3614082-3614492 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGGGACCTGCGCCGGATGCTGTTGCAACAAACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT115732 WP_010435322.1 NZ_CP034336:3613835-3614101 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT115732 NZ_CP034336:3613835-3614101 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTTGAATATGAGTATGACAGCTTAAGCGACGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References